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抗N-甲基-D-天冬氨酸受体脑炎研究新进展 被引量：13

Recent advance in anti-N-methyl-D-aspartate receptor encephalitis
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摘要 抗N-甲基-D-天冬氨酸受体（N-methyl-D-aspartate receptor,NMDAR）脑炎是近年明确的一种自身免疫性脑病,具有潜在致死性,因特殊临床表现及临床预后较好而引起广泛关注. 2005年Vitaliani等[1]首次报道了一组综合征：4例伴有卵巢畸胎瘤年轻女性患者出现急性精神症状、癫痫、记忆缺失、意识水平下降、中枢性通气不足等表现,最初考虑为副癌综合征的一种,通过免疫抑制剂及肿瘤切除治疗后3例患者痊愈.2007年从上述4例和其他具有类似症状的8例患者的血清或脑脊液中分离出了抗NMDAR自身抗体,将该综合征命名为抗NMDAR脑炎[2].
作者 龚帆 俞晓飞
机构地区 上海中医药大学附属曙光医院脑病科
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2014年第5期537-540,共4页 Chinese Journal of Neuromedicine
基金 上海高校中青年教师国外访学计划 上海中医药大学后备业务专家培养项目（EX-2011-上中大-医-004）
关键词 抗N-甲基-D-天冬氨酸受体脑炎 卵巢畸胎瘤 免疫治疗 Anti-NMDA receptor encephalitis Ovarian teratomas Immunotherapy
分类号 R742 [医药卫生—神经病学与精神病学]
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参考文献37

  • 1Vitaliani R,Mason W,Dalmau J,et al.Paraneoplastic encephalitis,psychiatric symptoms,and hypoventilation in ovarian teratoma[J].Ann Neurol,2005,58(4):594-604.
  • 2Dalmau J,Tuzun E,Wu HY,et al.Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma[J].Ann Neurol,2007,61 (1):25-36.
  • 3Titulaer MJ,McCracken L,Gabilondo I,et al.Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis:an observational cohort study[J].Lancet Neurol,2013,12(2):157-165.
  • 4Granerod J,Ambrose HE,Davies NW,et al.Causes of encephalitis and differences in their clinical presentations in England:a multicentre,population-based prospective study[J].Lancet Infect Dis,2010,10(12):835-844.
  • 5Gable MS,Sheriff H,Dalmau J,et al.The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project[J].Clin Infect Dis,2012,54(7):899-904.
  • 6宋旭霞,付先军,曲毅,邢振华.抗N-甲基-D-门冬氨酸受体脑炎[J].中华神经医学杂志,2010,9(11):1182-1185. 被引量：5
  • 7Lau CG,Zukin RS.NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders[J].Nat Rev Neurosci,2007,8(6):413-426.
  • 8Titulaer MJ,Kayser MS,Dalmau J.Authors' reply[J].Lancet Neurol,2013,12(5):425-426.
  • 9Iizuka T,Sakai F,Mochizuki H.Update on anti-NMDA receptor encephalitis[J].Brain Nerve,2010,62(4):331-338.
  • 10Iizuka T.Unique clinical features and pathophysiology of anti-NMDA receptor encephalitis[J].Rinsho Shinkeigaku,2009,49(11):774-778.

二级参考文献47

  • 1Dalmau J,Gleichman AJ,Hughes EG,et al.Anti-NMDA-receptor encephalitis:case series and analysis of the effects of antibodies.Lancet Neurol,2008,7:1091-1098.
  • 2Dalmau J,Tüzün E,Wu HY,et al.Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.Ann Neurol,2007,61:25-36.
  • 3Lebas A,Husson B,Didelot A,et al.Expanding spectrum of encephalitis with NMDA receptor antibodies in young children.J Child Neurol,2010,25:742-745.
  • 4Ances BM,Vitaliani R,Taylor RA,et al.Treatment-responsive limbic encephalitis identified by neurophil antibodies:MRI and PET correlates.Brain,2005,128:1764-1777.
  • 5Iizuka T,Sakai F,Ide T,et al.Anti-NMDA receptor encephalitis in Japan:long-term outcome without tumor removal.Neurology,2008,70:504-511.
  • 6Ishiura H,Matsuda S,Higashihara M,et al.Response of antiNMDA receptor encephalitis without tumor to immunotherapy including rituximab.Neurology,2008,71:1921-1923.
  • 7Vincent A,Buckley C,Schott JM,et al.Potassium channel antibody-associated encephalopathy:a potentially immunotherapy responsive form of limbic encephalitis.Brain,2004,127:701-712.
  • 8Gultekin SH,Rosenfeld MR,Voltz R,et al.Paraneoplastic limbic encephalitis:neurologic symptoms,immunobiological findings and tumour association in 50 patients.Brain,2000,123:1481-1494.
  • 9Chong JY,Rowland LP,Utiger RD.Hashimoto encephalopathy.Syndrome or myth? Arch Neurol,2003,60:164-171.
  • 10Dalmau J, Tfizfin E, Wu HY, et al. Paraneoplastic anti-N- Methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol, 2007, 61: 25-36.

共引文献157

同被引文献122

  • 1陈敏.呼吸机相关肺炎的研究现状[J].首都医药,2005,12(20):34-37. 被引量：3
  • 2Dalmau J, Gleichman AJ, Hughes EG, et al. Anti NMDA-re- ceptor encephalitis:case series and analysis of the efects of an tibodies . Lancet Neurol, 2008,7 (12) : 1091 -1098.
  • 3Granerod J,Ambrose HE,Davies NW,et al. Causes of enceph alitis and differences in their clinical presentations in England:a multicentre, population-based prospective study. Lancet Infect Dis, 2010, I0 (12) : 835-844.
  • 4Gable Ms, sheriff H, Dalmau J, et al. The frequency of autoim mune N methyl I)asparate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the Califomia Encephalitis Project. Clin Infect Dis, 2012,54 (7) ,899-904.
  • 5Dale RC, Irani SR, Brilot F, et al. N-Methyl-D-Aspartate recep tot antibodies in pediatric dyskinetic encephalitis lethargica. Ann Neurol, 2009,66(5) 704-709.
  • 6Baltagi SA, Shoykhet M, Felmet K, et al. Neurological sequelae of 2009 influenza A (H1N1) in children: a case series observed during a pandemic. Pediatr Crit Care Med, 2010, 11 (23) 179-184.
  • 7Datmau J, Tuzun E, Wu HY, et al. Paraneoplastic anti-N-methyl- D-aspartate receptor encephalitis associated with ovarian tera- toma. Ann Neurol, 2007,61 (1) : 25-36.
  • 8Vitaliani R, Mason W, Dalmau J, et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma [J]. Ann Neurol, 2005, 58(4): 594-604.
  • 9lizuka T, Sakai F, Ide T, et al. Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal [J]. Neurology, 2008, 70(7): 504-511.
  • 10Sansing LH, Tiiziin E, Ko MW, et al. A patient with encephalitis as- sociated with NMDA receptor antibodies [J]. Nat Clin Pract Neurol, 2007, 3(5): 291-296.

引证文献13

二级引证文献56

中华神经医学杂志
2014年 第5期

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