摘要
随着高性能战斗机和航天宇宙飞船的应用,高空环境对飞行员的损伤给他们带来了严峻的挑战.其中,正加速度(+Gz)暴露后消化性溃疡的发病率和复发率在进一步提高.溃疡复发是现代医学的难点,与溃疡愈合质量(quality of ulcer healing,QOUH)密切相关,提高QOUH被认为是对消化性溃疡认识的第3次飞跃,已成为目前航天航空医学的主要研究热点.本文从胃溃疡动物模型的建立、溃疡愈合质量的评价、+Gz对溃疡愈合质量影响的相关因素、实际应用等方面,对+Gz对大鼠实验性QOUH影响的研究进展进行综述,旨在促进相关的应用基础研究和提高针对高+Gz损伤的胃肠防护,进而增强飞行员的整体抗+Gz能力,提高飞行的安全性.
Injuries associated with high-performance fighter aircrafts and spacecrafts are bringing serious challenges to pilots. Exposure to positive acceleration （＋Gz） can increase the incidence and recurrence of peptic ulcer. Recurrence of ulcer is closely related to quality of ulcer healing （QOUH）, and improving QOUH is considered to be the third leap of understanding of peptic ulcer and has become a hotspot of aerospace medicine research. In this paper, we review the recent advances in understanding the effects of ＋Gz exposure on QOUH in rats with experimental gastric ulcer in terms of animal model development, QOUH assessment, and influencing factors for QOUH, with an aim to improve the protection against injuries caused by ＋Gz exposure, strengthen the pilot＇s overall ability to resist ＋Gz, and enhance the safety of flight.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第10期1359-1364,共6页
World Chinese Journal of Digestology
基金
全军十二五后勤科研计划基金资助项目
No.AKJ11J004~~
