摘要
目的探讨培美曲塞（PMT）联合顺铂（DDP）治疗晚期非鳞型非小细胞肺癌（NSCLC）的疗效及不良反应。方法收集92例经病理组织学或细胞学确诊的晚期非鳞型NSCLC患者,将其随机分为观察组和对照组,观察组42例,接受PMT联合DDP方案化疗：PMT 500 mg/m2静滴,第1天,联合DDP 25 mg/m2第1-3天。对照组50例,接受多西他赛（DOC）联合DDP方案化疗：DPC 75 mg/m2静滴,第1天,联合DDP 25 mg/m2第1-3天。2组治疗周期均为每3周1次。每例患者均治疗＆gt;2个周期,观察2组疗效和不良反应。结果 92例患者完全缓解（CR）5例,部分缓解（PR）34例,稳定（SD）39例,进展（PD）14例。观察组总有效率为52.4%,对照组总有效率为34.0%,2组间比较无统计学差异;观察组主要不良反应包括骨髓抑制、胃肠道反应、脱发等,发生率显著低于对照组（P〈0.05或0.01）,且以Ⅰ-Ⅱ级为主。结论 PMT联合DDP方案治疗晚期非鳞型NSCLC疗效与DOC联合DDP方案的疗效相当,但PMT联合DDP的不良反应发生率低,耐受较好。
Objective To investigate the clinical efficacy of pemetrexed combined with cisplatin in the treatment for advanced non-small cell lung cancer. Methods Ninety-two patients with advanced non-squamous NSCLC confirmed with pathology or cytology were enrolled in this study.The patients were divided into observation group and contrast group randomly. Observation group （42 cases） received treatment of pemetrexed（ 500 mg/m2 by iv infusion on dl ） combined with isplatin （25 mg/m2 by iv infusion on dl-3）. Control group received docetaxel （75 mg/m2 by iv infusion on dl and cisplatin 25 mg/m2 by iv infusion on dl-3）. The treatment cycle was once every three weeks. Each patient received at least 2 cycles. The efficacy and side effects were observed. Results The efficacy of the 92 patients were evaluated. Five cases got complete regression （CR） ,34 achieved partial regression （PR） ,39 achieved stable disease （SD） and 14 achieved progressive disease （PD）. The effective rate of observation group and control group was 52. 4% and 34. 0% （P〉O. 05）. The incidence rate of the main side effects such as myelosuppression, gastrointestinal response and peripheral neurotoxicity in the observa- tion group was significantly higher than that in control group. The side effects were mainly in grade 1-2. Conclusions The clinical efficacy of pemetrexed and docetaxel combined with cisplatin for the treatment of previously untreated advanced NSCLC is roughly the same, but the adverse reactions decrease significantly in the patients receiving the treatment of pemetrexed.
出处
《实用老年医学》
CAS
2014年第5期400-402,共3页
Practical Geriatrics
关键词
非小细胞肺癌
培美曲塞
顺铂
化学治疗
non-small cell lung cancer
pemetrexed
cisplatin
chemotherapy
