摘要
目的探讨IL-32和IL-18在骨关节炎发病中的表达及相关性,以了解IL-32在骨关节炎发病中的意义。方法研究对象包括膝骨关节炎患者62例,正常人31例;应用酶联免疫吸附测定IL-32和IL-18在骨关节炎患者关节滑液中的表达,分析IL-32和IL-18在膝骨关节炎关节滑液中的相关性。结果 IL-32和IL-18两个指标的试验组与对照组比较差异有统计学意义(P<0.01),表示IL-32和IL-18两个指标在骨关节炎关节滑液中表达与正常人的关节滑液比较异常增高。IL-32和IL-18的表达水平作Spearman相关分析,相关系数分别为r=0.908(P<0.01),呈正相关。结论骨关节炎的发病过程中可能与IL-32密切相关,IL-32和IL-18呈正相关。
【Objective】To investigate the expression and correlation of IL-32 and IL-18 in the development of osteoarthritis, to understanding IL-32 and IL-18 in the pathogenesis of osteoarthritis.【Methods】The Research included 62 cases of knee osteoarthritis patients, 31 cases of normal controls.Enzyme linked immunosorbent assay was used to detect the expression of IL-32 and IL-18 in patients with osteoarthritis in joint synovial fluid. Relevance of IL-32 and IL-18 analysised in the knee osteoarthritis of joint synovial fluid.【Results】In the IL-32 and IL-18 compared with the experimental group and the control group had statistical significance（P〈0.01）, IL-32 and IL-18 expression in synovial fluid and normal people in osteoarthritic synovial fluid is abnormal increase. Spearman correlation analysised for the expression levels of IL-32 and IL-18, the correlation coefficient were r=0.908（P〈0.01）, positived correlation.【Conclusion】The pathogenesis of osteoarthritis may be closely related to IL-32, IL-32 and IL-18 in which there is a positive correlation of relationship.
出处
《中国医学工程》
2014年第4期22-23,共2页
China Medical Engineering
