摘要
目的探讨低分化鼻咽癌组织中环氧化酶2(COX-2)表达与鼻咽癌颈淋巴结转移的关系。方法选择以2003年1月至2012年7月在郑州大学第一附属医院确诊的低分化鼻咽癌患者为研究对象,依据患者标本中COX-2表达情况进行分组:COX-2高表达组和COX-2低表达组,采用回顾性分析的方法分析COX-2表达及与鼻咽癌颈淋巴结转移的关系对预后的影响。结果104例患者COX-2染色的总体阳性率为78.8%(82/104),其中伴有颈部淋巴结转移者COX-2染色阳性率显著高于无颈部淋巴结转移组(84.5%与55.0%,x^2=6.765P=0.009)。进一步比较发现,年龄〈45岁和有颈部淋巴结转移的患者COX-2高表达率显著高于年龄≥45岁和无颈淋巴结转移的患者,分别为58.7%与37.7%,x^2=4.439,P=0.035和52.4%与25.0%,x^2=4.861,P=0.027。随访结束时,COX-2高表达组和COX-2低表达组的复发率分别为32.7%(16/49)和14.6%(8/55),差异具有统计学意(x^2=4.786,P=0.029)。与COX-2高表达组比较,COX-2低表达组转移发生率显著降低,为17.7%与28.6%,x^2=4.037P=0.045。进一步多因素Logistic回归分析显示,COX-2高表达是鼻咽癌复发的危险因素[OR=2.039,95%CI(1.042—5.875)]。结论低分化鼻咽癌组织中COX-2表达增加,是影响患者预后的一个危险因素。
Objective To explore the expression of cyclooxygenase-2 (COX-2) in lowly differentiated nasopharyngeal carcinoma and examine its relationship with cervical lymph node metastasis. Methods On the basis of COX expression, a total of 104 patients with lowly differentiated squamous cell carcinoma NPC were divided into 2 groups of COX-2 high-expression and COX-2 low-expression. The influence on prognosis was assessed by retrospective analysis. Results The overall positive rate for COX-2 staining was 78.8% (82/104). The rate of patients with lymph node metastasis was significantly higher than that in those without ( 84. 5% vs 55.0% , x^2 = 6. 765, P = 0. 009 ) . Further comparison showed that patients with age 〈 45 years and neck lymph node metastasis had higher rate of COX-2 high expression than those with age 〉 45 years and no cervical lymph node metastasis ( 58.7% vs 37. 7%, X2 = 4. 439, P = 0. 035 ; 52.4% vs 25.0%, x^2 = 4. 861, P = 0. 027 ). At the end of follow-up, the recurrence rate with inter-group statistical differences ( x^2 = 4. 786, P = 0. 029) was 32. 7% ( 16/49 ) and 14. 6% ( 8/55 ) respectively. Meanwhile, as compared with COX-2 high-expression group, the transferring rate in COX-2 low-expression group significantly decreased ( 17.7% vs 28.6%, x^2 = 4. 037, P = 0. 045 ) . Multiple logistic regression analysis showed that COX-2 high expression was a risk factor of nasopharyngeal carcinoma recurrence [ OR = 2. 039, 95% CI ( 1. 042 - 5. 875 ) ]. Conclusion COX-2 expression is up-regulated in lowly differentiated nasopharyngeal carcinoma tissues. And it may be risk factor influencing the prognosis of NPC.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2014年第18期1409-1412,共4页
National Medical Journal of China
关键词
鼻咽肿瘤
低分化
环氧化酶2
预后
Nasopharyngeal Neoplasms
Low differentiation
Cyclooxygenase-2
Prognosis