摘要
脑钠肽(BNP)或N端脑钠肽前体(NT-proBNP)已广泛用于心力衰竭的诊断、治疗及预后分析中。近来研究表明,BNP及NT-proBNP参与心肌缺血缺氧的早期病理过程,与常规心肌损伤标志物比较,有助于心肌缺血缺氧损伤的早期诊断,而且特异性和敏感性较高。BNP的合成与缺氧诱导因子(HIF)相关,人们试图通过HIF-1α类似物,诱导BNP合成以保护心肌。另外发现,排除心室室壁张力后,心肌缺氧缺血能直接诱导BNP合成,打破了传统的通过机械张力诱导或促进BNP合成的固有理论。
B-type natriuretic peptides （BNP）or N-terminal pro-B-type natriuretic peptides （NT-proBNP）has been widely used for diagnosis, treatment and prognostic analysis of heart failure. Recently it is said thatBNP and NT-proBNP, which participate in early period of pathological mechanism of myocardial ischemia orhypoxia, help to make earlier diagnosis than routine serological markers of myocardial injury, and have higherspecificity and sensibility. Finding that hypoxia-inducible transcription factor（HIF-la） induces BNP synthesisunder myocardial ischemia or hypoxia,researchers try to protect myocardial cell by HIF-la analogue inducingBNP synthesis. It＇s also discovered that myocardial ischemia or hypoxia without ventricular wall tensiondirectly induces BNP synthesis, which breaks the conventional theory that mechanical tension induces orpromotes BNP synthesis.
出处
《医学综述》
2014年第8期1374-1376,共3页
Medical Recapitulate
关键词
冠状动脉粥样硬化性心脏病
脑钠肽
N端脑钠肽前体
急性心肌梗死
Coronary atherosclerotie heart disease
B-type natriuretic peptides
N-terminal pro-B-typenatriuretic peptides
Acute myocardial infarction
