期刊文献+

肺癌和乳腺癌调强放疗致动态心电图改变的相关因素分析 被引量:11

A clinical study of the influential factors of dynamic electrocardiogram changes after intensity modulated radiation therapy for the lung cancer and breast cancer
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摘要 目的探讨肺癌和乳腺癌调强放疗(IMRT)后动态心电图(DCG)改变的相关因素。方法收集接受IMRT左肺癌43例和左乳腺癌39例,分别于治疗前后进行24hDCG监测,分析患者临床资料及剂量-体积直方图(DVH)参数对IMRT后DCG改变的影响。结果 IMRT后出现DCG改变32例(占39%),将患者临床资料及DVH参数进行Logistic分析,发现性别(OR=1.52,P<0.05)、心脏V40>22%(OR=1.15,P<0.05)与DCG改变密切相关。结论肺癌和乳腺癌患者IMRT治疗后以偶发房(室)性心律失常、ST-T改变为主,性别及心脏V40是其发生的独立危险因素。 Objective To study of the influential factors of dynamic electrocardiogram (DCG)changes after intensity modulated radiation therapy(IMRT) for the lung cancer and breast cancer .Methods IMRT was delivered to 43 patients with lung cancer and 39 patients with breast cancer ,and they were installed DCG before and after the therapy .The associations of clinical and DVH fac‐tors with DCG changed after IMRT were analyzed .Results 32 patients have abnormal DCG after IMRT (39% ) ,the clinical data and physical factors were analyzed by Logistic regression ,gender(OR=1 .52 ,P〈0 .05) and heart V40〉22% (OR=1 .15 ,P〈0 .05) were the independent influencing factors for abnormal DCG .Conclusion The rate of abnormal DCG is low after IMRT for the lung cancer and breast cancer ,and gender and heart V40 were the independent influencing factors for abnormal DCG .
出处 《重庆医学》 CAS CSCD 北大核心 2014年第15期1840-1842,1845,共4页 Chongqing medicine
基金 广西科学研究与技术开发基金资助项目(桂科攻1355005-3-14) 广西卫生厅重点课题基金资助项目(桂卫重2012103) 南宁市青秀区科学研究与技术开发基金资助项目(2012S04)
关键词 胸部肿瘤 调强放射治疗 动态心电图 剂量-体积直方图 thoracic neoplasms intensity modulated radiation therapy dynamic electrocardiogram dose volume histogram
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参考文献15

  • 1Stewart FA, Seemann I, Hoving S, et al. Understanding Radiation- induced cardiovascular damage and strategies for intervention[J]. Clin Oncol, 2013,25 (10) : 617-624.
  • 2Stewart FA. Mechanisms and dose-response relationships for radiation-induced cardiovascular disease [J]. Ann ICRP,2012,41 (3/4) :72-79.
  • 3王军,王祎,刘青,程云杰,曹峰,龙书敬,尚凯,景绍武.三维放疗急性放射性心脏损伤类型及影响因素分析[J].中华放射肿瘤学杂志,2013,22(3):213-216. 被引量:43
  • 4Kruse J J, Zurcher C, Strootman EG, et al, Structural chan ges in the auricles of the rat heart after local ionizing irra diation[J]. Radiother Oncol,2001,58(3) :303-311.
  • 5杨苏萍,张琴,蒿艳蓉,覃晓波,陈晓婕.胸部肿瘤放化疗致心电学指标改变的研究[J].重庆医学,2012,41(3):233-234. 被引量:14
  • 6Gustavsson A, Osterman B, Cavalln-stah L. A systematic over view of radia-lion therapy effects in Hodgkin's lym- phoma[J]. Acta Oncologica, 2003,42 (6) . 605-619.
  • 7Giraud P, Cosset JM. Radiation toxicity to the heart: physiopathology and clinical data[J]. Bull Cancer, 2004, 91(2) :147-153.
  • 8Emami B, Lyman J, Brown A, et ai. Tolerance of normal tissue to therapeutic irradiation[J]. J Radiat Oncol Boil Phys,2009,3(7) .1195 -1199.
  • 9付雷,胡立宽,闵瑞,竺鑫丽,宋轶鹏,张帅,许曼.肺癌大剂量常规分次三维适形放疗对心脏的影响[J].山东大学学报(医学版),2008,46(12):1173-1176. 被引量:10
  • 10黄志松,杨燕琼,张代平.肿瘤适形放疗与常规放疗致心电图改变的对比分析[J].肿瘤防治研究,2004,31(7):435-436. 被引量:8

二级参考文献50

  • 1梅审之,刘秋芳,谭丽,孙英.86例胸部肿瘤放射治疗心电图改变[J].现代肿瘤医学,2005,13(3):410-411. 被引量:10
  • 2陈峥,曹淑华,宋丽云.心脏放射损伤心电图改变的分析[J].实用医技杂志,2005,12(06A):1397-1398. 被引量:3
  • 3姜志荣,吕慧霞,刘培京,李大海,何信佳.超声心动图评价蒽环类药对乳腺癌患者心脏毒性[J].中国医学影像技术,2005,21(8):1209-1212. 被引量:9
  • 4范风云,石梅,张丙芳.放射性心脏损伤及防护的研究进展[J].心脏杂志,2006,18(6):721-723. 被引量:29
  • 5Thirion P, Hohnberg O, Collins C D, et al. Escalated dose for Non-small-cell hmg cancer with accelerated hypofractionated three-dimensional conformal radiation therapy [ J]. Radiother Oncol, 2004, 71(2):163-166.
  • 6Prosnitz R G, Marks L B. Radiation-induced heart disease: vigilance is still required [ J ]. J Clin Oncol, 2005, 23 (30) : 7475-7482.
  • 7Marks L B, Yu X, Prosnitz R G, et al. The incidence and functional consequences of RT-associated cardiac perfusion defects[ J ]. Int J Radiat Oncol Biol Phys, 2005, 63 ( 1 ) : 214- 223.
  • 8Kruse J J, Zurcher C, Strootman E G, et al. Structural changes in the auricles of the rat heart after local ionizing irradiation [J]. Radiother Oncol, 2001, 58(3) :303-311.
  • 9Colucci W S. Apoptosis in the heart[J]. N Engl J Med, 1996, 335(16) : 1224-1226.
  • 10Mao X W. A quantitative study of the effects of ionizing radiation on endothelial cells and capillary-like network formation [J]. Technol Cancer Res Treat, 2005, 5(2) : 127-134.

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