摘要
目的:研究哮喘患者血清中白细胞介素-4、白细胞介素-12、白细胞介素-13、γ干扰素、免疫球蛋白E水平的测定及临床意义。方法:采用生物素亲合素双抗体夹心酶联和间接酶联免疫吸附法测定98例哮喘患者不同分期和分级血清IL-4、IL-12、IL-13以及IFN-γ水平和IgE水平,观察不同分期和分级各项观察指标的水平,并与60例健康对照组进行比较。结果:观察组及发作期患者IL-4、IL-13、IgE水平均明显升高(P<0.05),IFN-γ、IL-12水平均明显降低(P<0.05)。结论:IL-4、IL-12、IL-13、IFN-γ、IgE在哮喘发病中起重要调控作用。
Objective： To investigate the changes of serum IL-4, IL-12, IL-13, IFN-＇y and IgE Levels and their clinical significance in acute attack of asthma.Method： Serum levels of IL-4, IL-12, IL-13, IFN- γ and IgE of 98 asthma patients in different periodizations and different classifications and its catabasis respectively were determined through double-antibody sandwich and indirect ELISA.Levels of IL-4, IL-12, IL-13, IFN-γ and IgE were compared between the observation group and the healthy control group （ 60 eases ） .Result： The levels of IL-4, IL-13, IgE of the observation group and acute attack stage increased significantly （ P〈0.05 ） .The levels of IFN- , IL-12 of the observation group and acute attack stage reduced significantly （P〈O.05） .Conclusion： IL-4, IL-12, IL-13, IFN-γand IgE play crucial roles in the pathogenesis of asthma.
出处
《中国医学创新》
CAS
2014年第14期41-43,共3页
Medical Innovation of China
