摘要
目的探讨血清心肌肌钙蛋白T(cTnT)、血浆氨基末端B型利钠肽前体(NT-proBNP)和肌红蛋白(Myo)联合检测在急性心肌梗死(AMI)诊断中的临床价值。方法选择以急性胸痛为主要症状的患者440例,将其分为AMI组和非AMI组,将220例健康者作为对照组。采用BECKMAN COULTER Access 2全自动微粒子化学发光免疫分析仪检测其血清NT-proBNP、cTnT及Myo浓度。结果 AMI组患者血清NT-proBNP、cTnT和Myo浓度分别为(3 546.12±220.95)pg/mL、(0.13±0.02)μg/L和(88.12±14.27)μg/L,显著高于非AMI组和对照组(P<0.05)。NT-proBNP、cTnT和Myo检测的受试者工作特征(ROC)曲线的曲线下面积(AUC)分别为0.809、0.851和0.749,cTnT检测的ROC曲线AUC显著高于Myo(P<0.05)。NTproBNP、cTnT及Myo联合检测的敏感性、特异性及诊断符合率分别为0.957、0.950及0.948,显著高于2种指标的联合检测(P<0.05)。结论血清NT-proBNP、cTnT和Myo联合检测能有效提高AMI诊断的敏感性、特异性及诊断符合率。
Objective To investigate the clinical significance of combined detection of serum cardiac troponin T （cTnT ） ,N-termi-nal pro-B-type natriuretic peptide（NT-proBNP） and myoglobin（Myo） in acute myocardial infarction diagnosis .Methods 440 pa-tients with main symptoms of acute chest pain were enrolled and divided into AMI group and non-AMI group ,and 220 healthy peo-ple were served as the control group .BECKMAN COULTER Access 2 automated chemiluminescent microparticle immunoassay analyzer was employed to detect their serum NT-proBNP ,cTnT and Myo concentrations .Results The serum concentrations of NT-proBNP ,cTnT and Myo of patients with AMI were （3 546 .12 ± 220 .95） pg/mL ,（0 .13 ± 0 .02）μg/L and （88 .12 ± 14 .27）μg/L , respectively ,which were significantly higher than those in non-AMI group and the control group（P〈0 .05） .Areas under the curve （AUC） of receiver operator characteristic（ROC） of NT-proBNP ,cTnT and Myo detection were 0 .809 ,0 .851 and 0 .749 ,respec-tively ,and the ROC curve AUC of cTnT detection was markedly higher than that of Myo （P〈0 .05） .The sensitivity ,specificity and diagnostic accuracy of combined detection of NT-proBNP ,cTnT and Myo were 0 .957 ,0 .950 and 0 .948 ,respectively ,which was significantly higher than those in combined detection of any two kinds of indicators （P〈0 .05） .Conclusion Combined detection of serum NT-proBNP ,cTnT and Myo can improve the sensitivity ,specificity and diagnostic accuracy in AMI diagnosis .
出处
《国际检验医学杂志》
CAS
2014年第9期1134-1135,1137,共3页
International Journal of Laboratory Medicine
关键词
心肌梗死
肌红蛋白
肌钙蛋白T
利钠肽
脑
诊断
myocardial infarction
myoglobin
troponin T
natriuretic peptide,brain
diagnosis
