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宝安区育龄妇女孕前TSH的检测分析及TPOAb筛查对优生优育意义的研究 被引量:10

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摘要 目的探讨宝安区育龄妇女孕前促甲状腺激素(TSH)及抗甲状腺过氧化物酶抗体(TPOAb)筛查对优生优育的意义。方法选择12 886例育龄妇女,采用化学发光分析法、Access2全自动化学发光免疫分析仪对所采集的血样进行TSH检测。TSH异常者,用酶联免疫法定性检测TPOAb;在TSH正常者中,随机抽取1 000例血样检测其TPOAb。结果 TSH正常12 158例,TSH异常728例。20~〈30岁TSH异常率为4.91%,30~〈40岁TSH异常率为5.94%,该2个年龄段的差异无统计学意义(P=0.058),30~〈40岁与40~〈45岁妇女TSH异常率的差异有统计学意义(P〈0.01)。TSH〈0.3mU/L的340例育龄妇女中,TPOAb阳性72例(21.2%);TSH〉4.8mU/L的388例中TPOAb阳性95例(24.5%)。TSH〉4.8mU/L与TSH〈0.3mU/L的育龄妇女TPOAb阳性检出率的差异无统计学意义(P=0.290)。TSH总体异常率为5.65%(728/12 886)。TPOAb总体阳性率为7.62%。TSH异常者中,TPOAb阳性167例(22.9%)。在TSH正常者中,随机抽取1 000例血样定性检测TPOAb,TPOAb阳性67例(6.7%),二者差异有统计学意义(P〈0.01)。结论宝安区育龄妇女孕前甲状腺功能异常率较高,应常规进行甲状腺功能检测。
出处 《国际检验医学杂志》 CAS 2014年第9期1210-1212,共3页 International Journal of Laboratory Medicine
基金 广东省人口和计划生育委员会科研项目(20133053)
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参考文献5

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共引文献42

同被引文献78

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