摘要
采用电化学发光法检测140名妊娠女性甲状腺功能及甲状腺自身抗体，根据血清TSH及FL水平分为正常组（n=117）和亚临床甲状腺功能减退组（亚甲减，n=23）。应用尿碘砷铈催化分光光度法检测孕妇尿碘水平。调查甲状腺功能异常组既往甲状腺病史知晓情况。结果显示，正常组与亚甲减组分别有50％、57％的女性具有不同程度碘缺乏，尿碘水平与甲状腺功能无显著相关。血清甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋A抗体水平与血清TSH显著相关（P〈0．01），TPOAb水平与血清FT4显著相关（P〈0．05）。亚甲减组中70％孕前未行甲状腺功能及自身抗体筛查，8．7％否认既往甲状腺疾病史，21．7％既往有甲状腺功能减退。因此，应支持孕前或孕早期常规筛查尿碘及甲状腺自身抗体，及时纠正碘缺乏，避免盲目过量补碘，改善围产期结局，并减少对子代的不利影响。
Electrochemiluminescence was used to determine thyroid function and thyroid autoantibodies in 140 pregnant women, who were then divided into normal group （ n = 117 ） and subclinical hypothyroidism group （ n = 23） based on the thyroid function. The urine iodine level in the pregnant women was detected by arsenic cerium catalytic spectrophotometric method. The awareness of past history of thyroid disease among the subjects with thyroid dysfunctions were investigated. The results showed that the prevalences of iodine deficiency were 50% and 57% in the normal group and the subclinical hypothyroidism group, respectively. The state of iodine level was not related to thyroid function. The levels of serum thyroid peroxidase antibody （TPOAb） and thyroglobulin antibody were markedly related to serum TSH（ P〈 0.01 ）, so was the level of serum TPOAb related to serum FT4 （P 〈 0.05 ）. Among the subclinical hypothyroidism women, 70% did not undergo thyroid function and thyroid autoantibodies screening before pregnancy, 8.7% denied past history of thyroid disease, and 21.7% suffered from hypothyroidism before pregnancy. Therefore, we advocate the screening of urine iodine and thyroid autoantibodies before or during the first trimester of pregnancy, aiming to correct iodine deficiency, avoid supplementing too much iodine, improve the outcome of perinatal stage, and reduce all the negative effects on the offsprings.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2014年第5期408-410,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
妊娠
甲状腺功能
甲状腺自身抗体
尿碘
Pregnancy
Thyroid function
Thyroid autoantibodies
Urine iodine
