摘要
发酵抑制物对宿主细胞产生毒害作用,是木质纤维素生物炼制的主要瓶颈之一。减少抑制物含量、解除抑制作用是提高发酵效率的重要环节。本文讨论了木质纤维素发酵抑制物的来源、组成、特点以及相应的解除方法,提出了"源头降低抑制物—纤维素木质素分级转化"炼制模式和"发酵促进剂设计技术",为木质纤维素发酵抑制物的解除及木质纤维素开发利用提供了全新的技术路线。
Fermentation inhibitors are toxic to cells, which is one of the bottlenecks for lignocellulose bio-refinery process. How to remove those inhibitors serves a key role in the bioconversion of lignocellulose. This article reviews the sources and the types of the inhibitors, especially the updated removal strategies including physical methods, chemical methods, biological methods and inhibitor-tolerant strain construction strategies. Based on these, we introduce a new bio-refinery model named ＂fractional conversion＂, which reduces the production of inhibitors at pretreatment stage, and a novel in situ detoxification method named ＂fermentation promoter exploitation technology＂. This review could provide new research ideas on the removal of fermentation inhibitors.
出处
《生物工程学报》
CAS
CSCD
北大核心
2014年第5期716-725,共10页
Chinese Journal of Biotechnology
基金
生物质炼制工程北京市重点实验室2013年度科技创新基地培育与发展工程专项项目(No.Z13111000280000)
国家高技术研究发展计划(863计划)(No.2012AA021302)
国家重点基础研究发展计划(973计划)(No.2011CB707401)资助~~
关键词
木质纤维素
发酵抑制物
源头解除抑制物
分级转化
发酵促进剂
lignocellulose, fermentation inhibitors, reducing inhibitors from the very beginning, fractional conversion,fermentation promoter
