摘要
目的:总结非小细胞肺癌EGFR突变状态与脑转移的研究进展,探讨EGFR突变非小细胞肺癌脑转移治疗策略。方法:应用PubMed和CNKI期刊全文检索系统,以"非小细胞肺癌脑转移、靶向治疗和全脑放疗"为关键词,共检索到2004-2013年相关文献270篇,其中英文文献160篇,中文文献110篇。纳入标准:1)非小细胞肺癌脑转移与EGFR突变状态关系;2)表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitors,EGFR-TKIs)在非小细胞肺癌脑转移中的作用;3)非小细胞肺癌脑转移全脑放疗。根据纳入标准分析文献30篇。结果:EGFR突变NSCLC脑转移患者TKIs治疗敏感,同时中枢转移灶放疗亦敏感,而EGFR野生型及TKIs获得性耐药患者中枢转移灶放疗抵抗;EGFR突变状态与NSCLC脑转移患者TKIs治疗疗效、放疗疗效、生存及预后明显相关。结论:EGFR基因突变状态在指导NSCLC脑转移患者治疗、预测预后方面具有重要的作用。
OBJECTIVE：To summarize the progress of brain metastasis in non-small cell lung cancer with different EGFR gene status,discuss non-small cell lung cancer with EGFR mutations brain metastasis treatment strategies.METHODS：The full text database of PubMed and CNKI were searched,and the words＂non-small cell lung cancer with brain metastasis＂,＂targeted therapy＂and＂whole-brain radiotherapy＂were used as key words.Totally 270related articles were retrieved between the year of 2004and 2013with 160papers of literature in English and 110in Chinese.The selection standards for the date related：1）Non-small cell lung cancer with brain metastasis relationship with EGFR mutation status; 2）Epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer with brain metastasis;3）Nonsmall cell lung cancer with brain metastasis whole brain radiotherapy.According to the standards mentioned above,30papers were finally selected and analyzed.RESULTS：NSCLC patients with brain metastases and EGFR mutations are sensitive to TKIs,but the central nervous metastases also are sensitive to radiotherapy,whereas the brain metastases patients with wild-type and TKIs acquired resistance are radiation resistance.There are significantly correlation between EGFR mutations status and NSCLC patients with brain metastases to TKIs therapy,radiotherapy,survival and prognosis.CONCLUSION：EGFR mutation status are impotant in guiding treatment,predicting the prognosis of NSCLC patients with brain metastases.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第10期795-799,共5页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(81172225)
关键词
非小细胞肺癌
脑转移
表皮生长因子受体
综述文献
non-small cell lung cancer
brain metastasis
epidermal growth factor receptor
literature review
