期刊文献+

别嘌醇对高尿酸血症扩张型心肌病患者心功能影响 被引量:4

The cardiac function effect of allopurinol for hyperuricemia combined with dilated cardiomyopathy patients
原文传递
导出
摘要 目的 探讨别嘌醇对高尿酸血症扩张型心肌病患者心功能的影响.方法 将120例高尿酸血症扩张型心肌病患者根据治疗方法不同分为别嘌醇组和对照组,每组60例.两组患者入院后均给予常规治疗,在此基础上对照组加用硝普钠治疗,而别嘌醇组加用别嘌醇和硝普钠治疗,两组均治疗3个月.结果 别嘌醇组总有效率明显高于对照组[90.0% (54/60)比75.0%(45/60)],差异有统计学意义(P<0.05).别嘌醇组治疗后左室射血分数和左室收缩末期后壁厚度明显高于对照组[(67.85±7.12)%比(30.78±7.00)%和(1.40±0.20) mm比(1.16±0.18) mm],而左室收缩末期内径、左室舒张末期内径和左室舒张末期后壁厚度明显低于对照组[(4.72±0.41) mm比(6.48±0.47) mm、(2.93±0.32) mm比(5.56±0.62) mm和(0.77±0.13) mm比(0.92±0.18) mm],差异均有统计学意义(P<0.05).别嘌醇组治疗后尿酸、尿素氮和肌酐均明显低于对照组[(45.43±11.24)μmol/L比(167.23±19.22) μmol/L、(10.23±7.12) mmol/L比(40.93±8.09) mmol/L和(32.01±8.34) mmol/L比(78.09±9.11) mmol/L],差异均有统计学意义(P<0.05).结论 别嘌醇在降低高尿酸血症扩张型心肌病患者尿酸的同时,可早期逆转动脉硬化,改善心功能,值得推广应用研究. Objective To study the cardiac function effect of allopurinol for hypemricemia combined with dilated cardiomyopathy patients.Methods One hundred and twenty hypemricemia combined with dilated cardiomyopathy patients were divided into allopurinol group and control group according to the treatment method with 60 cases each.All the patients were given conventional treatment,the control group was added the nitroprusside treatment,and the allopurinol group was added the allopurinol and nitroprusside treatment.The treatment period was 3 months.Results The total effective rate in allopurinol group was significantly higher than that in control group [90.0% (54/60) vs.75.0% (45/60)],there was statistical difference (P 〈 0.05).After treatment,the left ventricular ejection fraction and left ventricular posterior wall thickness at end-systole in allopurinol group were significantly higher than those in control group [(67.85 ± 7.12)% vs.(30.78 ±7.00)% and (1.40 ±0.20) mm vs.(1.16 ±0.18) mm[,but the left ventricular internal diameter at end-systole,left ventricular internal diameter at end-diastole and left ventricular posterior wall thickness at end-diastole were significantly lower than those in control group [(4.72 ± 0.41) mm vs.(6.48 ± 0.47) mm,(2.93 ± 0.32) mm vs.(5.56 ± 0.62) mm and (0.77 ± 0.13) mm vs.(0.92 ± 0.18) mm],there were statistical differences (P 〈 0.05).After treatment,The uric acid,urea nitrogen and creatinine were significantly lower than those in control group [(45.43 ± 11.24) μ mol/L vs.(167.23 ± 19.22) μ mol/L,(10.23 ± 7.12)mmol/L vs.(40.93 ± 8.09)mmol/L and (32.01 ± 8.34) mmol/L vs.(78.09 ±9.11) mmol/L],there were statistical differences (P 〈 0.05).Conclusion Allopurinol used for treating hyperuricemia combined with dilated cardiomyopathy patients can reduce uric acid,early reversal the atherosclerosis and improve heart function,it should be widely applied research.
出处 《中国医师进修杂志》 2014年第14期48-51,共4页 Chinese Journal of Postgraduates of Medicine
关键词 别嘌呤醇 高尿酸血症 心肌病 扩张型 Allopurinol Hyperuricemia Cardiomyopathy,dilated
  • 相关文献

参考文献15

二级参考文献36

  • 1黄玉斌.381例别嘌醇不良反应分析[J].中国药物应用与监测,2005,2(1):32-34. 被引量:23
  • 2平成斌,陈冠容.别嘌醇的药理作用及其临床新用途[J].中国社区医师,2007,23(3):19-20. 被引量:12
  • 3中华医学会心血管病分会.心血管疾病防治指南和共识[C].2011,100.
  • 4Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension [J]. JAMA, 2008,300(8):924-932.
  • 5Doehner W, Anker SD. Uric acid in chronic heart failure[J]. Ser- ain Nephol, 2005,25( 1 ) :61-66.
  • 6Meisinger C, Koeniq W, Baument J, et al. Uric acid levels are as- sociated with allcause and cardiovascular disease mortality inde- pendent of Systemic inflammation in men from the gengral popula- tion :The MOMICA/KORA cohort study [ J ]. Arterioseler Thromb Vase Biol, 2008,28 (6) : 1186-1192.
  • 7Krishnan E, Baker JF, Furst DE, et al. Gout and the risk of acute myocardial infarction [ J ]. Arthritis Rheum, 2006,54 ( 8 ) : 2688- 2696.
  • 8Bos M J, Koudstaal PJ, Hofman A, et al. Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdarm Study [ J ]. Stroke, 2006,37 (6) : 1503-1507.
  • 9Sin Y, Leung K, Tong M, et al. Use of allopurinol in showing the propression of renal diseased through its ability to lower serum uric acid level[J]. Am J Kinduey Dis, 2006,47( 1 ) :51-59.
  • 10陈灏珠.实用内科学[M]11版[M].北京:人民卫生出版社,2001.957-959.

共引文献58

同被引文献33

引证文献4

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部