摘要
吸血是蚊虫传染疾病的主要途径。吸血前后,蚊虫体内的代谢途径会发生一系列变化。转录组分析可以从整体水平上反映细胞中基因表达情及调控规律。特对蚊虫吸血前后基因表达及代谢途径等变化进行综述。
Hematophagy,blood-feeding,is a behaviour exhibited by most arthropod vectors of human pathogens.Hematophagous mosquitoes can transmit many diseases by blood feeding.It causes a large number of deaths each year all over the world.The female generally feeds to repletion on a single blood meal and then proceeds to use this nutrition as the basis for the development of batch of eggs.A series of changes such as gene expression may occur after blood meal.Availability of several mosquitoes＇ genome sequences provides unique opportunities to study different aspects of biology,including identification of genes and pathways relevant to the developmental processes of individual life stages.However,development of novel vector control strategies requires a thorough detailed understanding of mosquito biology.Transcriptome analysis is a recently developed approach to transcriptome profiling that uses deep-sequencing technologies.It provides a comprehensive understanding of gene expression and its regulation.It also provides a far more precise measurement of levels of transcripts and their isoforms than any other methods.Transcriptome analysis has been successfully used in several mosquitoes and also achieved much useful information.Females of non-blood-feeding and blood feeding differ in many morphological,behavioural,and physiological traits,largely caused by differences in gene expression.The expression patterns of different genes are discussed in the context of female mosquitoes＇ physiological responses to blood feeding,including blood digestion,peritrophic matrix formation,egg development,and immunity.The changes of gene expression expose the main molecular differences between non blood-feeding female and blood-feeding female.The present paper would summarize the current status of the transcriptome changes in mosquitoes induced by blood-feeding.It provides a valuable resource for the future studies.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2014年第5期527-530,共4页
Chinese Journal of Zoonoses
基金
福建省自然科学基金项目(No.2013J01266)
国家质检总局科技计划项目(No.2014IK058)
中国博士后科学基金第51批面上资助项目(No.2012M12111)~~
关键词
蚊虫
转录组
血餐
mosquito
transcriptome
blood meal
