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促性腺激素释放激素拮抗剂固定方案对卵巢储备功能正常的不孕患者的影响 被引量：2

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摘要 促性腺激素释放激素（gonadotropin-releasing hormone,GnRH）激动剂方案是目前临床上广泛采用的超促排卵方案,但是GnRH激动剂方案存在治疗周期长,治疗费用高,卵巢过度刺激综合征（OHSS）发生率高等缺点,给临床应用带来许多不便,甚至可以严重危害患者的身体健康[1-2].20世纪末,GnRH拮抗剂开始逐步在临床进行应用,在西方发达国家GnRH拮抗剂的使用比例不断提高,并且有取代GnRH激动剂的趋势[3-4],但是国内对于GnRH拮抗剂的研究报道较少,为此本研究对50例卵巢储备功能正常的不孕症患者采用GnRH拮抗剂固定方案进行治疗,现报道如下.
作者 董晓娟 王妍
机构地区 上海市第六人民医院金山分院妇产科
出处 《中华临床医师杂志（电子版）》 CAS 2013年第6期195-196,共2页 Chinese Journal of Clinicians(Electronic Edition)
基金 国家自然科学基金(30973193)
关键词 促性腺激素释放激素拮抗剂 卵巢储备功能 不孕患者 固定方 GNRH拮抗剂 GNRH激动剂 卵巢过度刺激综合征 临床应用
分类号 R714.8 [医药卫生—妇产科学]
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参考文献6

  • 1赵冬梅,谭丽,李月白,项云改.促性腺激素释放激素拮抗剂联合促性腺激素超排卵效果观察[J].郑州大学学报（医学版）,2008,43(6):1192-1195. 被引量：3
  • 2Griesinger G,Venetis CA,Marx T,et al.Oral contraceptive pill pretreatment in ovarian stimulation with GnRH antagonists for IVF:a systematic review and meta-analysis[].Fertility and Sterility.2008
  • 3Royster GD,Retzloff MG,Robinson RD,et al.Effect of length of con-trolled ovarian hyperstimulation using a gonadotropin-releasing hor-mone antagonist on in vitro fertilization pregnancy rates[].Journal of Reproductive Medicine.2012
  • 4Abuzeid MI,Mitwally M,Abuzeid YM,et al.Early initiation of gona-dotropin-releasing hormone antagonist in polycystic ovarian syndrome patients undergoing assisted reproduction:randomized controlled trial ISRCTN69937179[].Journal of Assisted Reproduction and Genetics.2012
  • 5Griesinger G,Diedrich K,Tarlatzis BC,et al.GnRH-antagonists in o-varian stimulation for IVF in patients with poor response to gonadotro-phins,polycystic ovary syndrome,and risk of ovarian hyperstimulation:a meta-analysis[].Reproductive Biomedicine Online.2006
  • 6Dal Prato L,Borini A.Use of antagonists in ovarian stimulation proto-cols[].Reproductive Biomedicine Online.2005

二级参考文献8

  • 1卢先艳,李艳萍.促性腺激素释放激素拮抗剂在辅助生殖技术中的应用[J].生殖与避孕,2004,24(3):186-190. 被引量：1
  • 2Ron-EL R, Henman A, Golan A, et al. Ultrashort gonadotropin-releasing hormone agonist (GnRH-a) protocol in comparison with the long-acting GnRH-a protocol and menotropin alone [ J ]. Fertil Steril, 1992,58 ( 6 ) : 1 164
  • 3Ludwig M,Felberbaum RE,Devroey P,et al. Significant reduction of the incidence of ovarian hyperstimulation syn-drome (OHSS) by using the LHRH antagonist Cetrorelix (Cetrotide) in controlled ovarian stimulation for assisted reproduction[ J]. Arch Gynecol Obstet,2000,264( 1 ) :29
  • 4Cheung LP, Lam PM, Lok IH, et al. GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial[ J ]. Hum Reprod, 2005,20( 3 ) :616
  • 5De Placido G, Mollo A, Clarizia R, et al. Gonadotropin-releasing hormone (GnRH) antagonist plus recomebinant luteinizing hormone vs a standard GnRH agonist short protocol in patients at risk for poor ovarian response [ J ]. Fertil Steril,2006,85 ( 1 ) :247
  • 6Borm G, Mannaerts B. Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective,safe and convenient:results of a controlled, randomized, muhicentre trial [ J ]. Hum Reprod, 2000,15(7) :1 490
  • 7Albano C, Felberbaum RE, Smitz J, et al. Ovarian stimulation with HMG :results of a prospective randomized phase Ⅲ European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin [ J ]. Hum Reprod,2000,15 ( 3 ) :526
  • 8Rombauts L, Healy D, Norman RJ, et al. A comparative randomized trial to assess the impact of oral contraceptive pretreatment on follicular growth and hormone profiles in GnRH antagonist-treated patients [ J ]. Hum Reprod, 2006, 21(1) :95

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二级引证文献51

中华临床医师杂志（电子版）
2013年 第6期

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