摘要
目的 观察螺内酯联合苯那普利治疗高血压性心脏病充血性心力衰竭的临床效果.方法 选择2012年6月～2013年12月本院接诊的80例高血压性心脏病充血性心力衰竭患者,按照随机数字表法分为观察组和对照组,对照组采用苯那普利治疗,观察组在对照组的基础上,采用螺内酯治疗.比较两组的疗效和不良反应发生率,治疗前后心功能相关指标、血压及心率.结果 两组治疗后的LAD、INS、LVEDD、LVEF及NT-pro-BNP改善均明显优于治疗前,观察组治疗后的LVPW改善优于治疗前,差异有统计学意义（P＜0.01）;观察组治疗后的LAD、INS、LVPW、LVEDD、LVEF及NT-pro-BNP改善均明显优于对照组,差异有统计学意义（P＜0.05）.两组治疗后的收缩压、舒张压及心率均明显低于治疗前,差异有统计学意义（P＜0.01）;观察组治疗后的收缩压、舒张压及心率均明显低于对照组,差异有统计学意义（P＜0.05）.观察组的总有效率为87.50％,明显高于对照组的67.50％,两组比较差异有统计学意义（u=-2.2686,P=0.0233）.两组的不良反应发生率比较差异无统计学意义（x2=0.6723,P=0.4123）.结论 螺内酯联合苯那普利治疗高血压性心脏病充血性心力衰竭的效果显著,安全性高,值得临床推广应用.
Objective To evaluate the clinical efficacy of spironolactone combined with benazepril in the treatment of hypertensive heart disease and congestive heart failure. Methods 80 cases of patients with hypertensive heart disease and congestive heart failure from June 2012 to December 2013 in our hospital were selected and divided into observa- tion group and control group according to a random number table method.Control group was treated with benazepril,on the basis of control group therapy,observation group was treated with spironolactone.The efficacy,incidence rate of ad- verse reaction,related index of heart function,blood pressure,heart rate before and after treatment in two groups was compared respectively. Results After treatment,LAD,INS,LVEDD,LVEF,NT-pro-BNP in two groups was better than that before treatment respectively,LVPW in observation group was better than that before treatment,with statistical dif- ference （P〈0.01）.Mter treatment,LAD,INS,LVPW,LVEDD,LVEF,NT-pro-BNP in observation group was better than that in control group,with statistical difference（P〈0.O5）.The systolic blood pressure,diastolic blood pressure and heart rate in two groups after treatment was significantly lower than that before treatment respectively,with statistical difference （P〈O.O1）.The systolic blood pressure,diastolic blood pressure and heart rate in observation group after treatment was significantly lower than that in control group respectively,with statistical difference （P〈0.05）.Total efficiency rate of ob- servation group was 87.50%,significantly higher than that of control group（67.50%）,with statistical difference（u=-2.2686, P=0.0233）.Incidence rate of adverse reaction in two groups was compared,with no statistical difference （χ2=0.6723, P=0.4123）. Conclusion The clinical efficacy of spironolactone combined with benazepril in the treatment of hyperten- sive heart disease and congestive heart failure is remarkable and safe,it is worthy of clinical promotion and application.
出处
《中国当代医药》
2014年第15期94-96,共3页
China Modern Medicine
关键词
高血压性心脏病
充血性心力衰竭
螺内酯
苯那普利
疗效
Hypertensive heart disease
Congestive heart failure
Spironolactone
Benazepril
Efficacy
