期刊文献+

CPP-ACP与含氟制剂抑制牙釉质脱矿效果比较的Meta分析

CPP-ACP Versus Fluoride Products in Inhibiting Enamel Demineralization:A Meta-Analysis
下载PDF
导出
摘要 目的:系统评价局部应用CPP-ACP与含氟制剂比较抑制牙釉质脱矿的临床效果。方法:计算机检索Pubmed、CNKI、CBM、VIP和WanFang Data数据库,查找CPP-ACP与含氟制剂比较抑制牙釉质脱矿的随机对照试验(RCT),并追溯纳入文献的参考文献,检索时间均为建库至2013年10月18日。由2名评价员按纳入和排除标准独立进行文献筛选、资料提取和评价纳入研究的方法学质量后,采用RevMan5.2软件进行Meta分析。结果:最终纳入7篇文献,11个RCT,共563例受试者。Meta分析结果显示:局部应用CPP-ACP后,其Diagnodent值[MD=2.30,95%CI(0.69,3.91),P=0.005]及脱矿率[OR=1.40,95%CI(1.09,1.81),P=0.009]明显低于局部应用含氟制剂,其差异有统计学意义。结论:在早期釉质龋、正畸治疗后出现的釉质白斑病损等牙釉质脱矿的预防和治疗方面,CPP-ACP具有优于含氟制剂的临床疗效,且不存在像含氟制剂的安全问题,因此,CPP-ACP作为一种新型再矿化剂有望替代含氟制剂发挥较优效果。 Objective:To evaluate the clinical effectiveness of CPP-ACP versus fluoride products in inhibiting enamel demineralization.Methods:PubMed,CNKI,CBM,VIP and WanFang Data were searched on computer for the randomized controlled trials(RCTs)of CPP-ACP versus fluoride products in inhibiting enamel demineralization from the date of their establishment to October 18,2013.The bibliographies of the included studies were searched. According to the inclusion and exclusion criteria,two reviewers independently screened studies,extracted data,and evaluated the methodological quality of the included RCTs.Then meta-analysis was performed using RevMan 5.2 software.Results:A total of 7papers,11RCTs,involving 563patients were included.The results of meta-analysis showed that after topical CPP-ACP,the Diagnodent values(MD=2.30,95%CI 0.69to 3.91,P=0.005)and the rate of enamel demineralization(OR=1.40,95%CI 1.09to 1.81,P=0.009)was lower than that of fluoride products, with significant differences.Conclusion:The clinical effectiveness and security of CPP-ACP is superior to fluoride products in the prevention and treatment of enamel demineralization like early enamel caries,white spot lesions after the orthodontic treatment and so on.Thus,CPP-ACP is promising to replace fluoride products as a new remineralizing materials.
出处 《口腔医学研究》 CAS CSCD 2014年第5期446-450,共5页 Journal of Oral Science Research
关键词 CPP-ACP 脱矿 随机对照试验 META分析 系统评价 CPP-ACP Fluorine Demineralization RCTs Meta-analysis Systematic review
  • 相关文献

参考文献12

  • 1樊明文.牙体牙髓病学[M].'北京:人民卫生出版社,2012.3.
  • 2应淑女,刘丽.牙釉质再矿化材料的研究进展[J].中华口腔医学研究杂志(电子版),2011,5(1):58-61. 被引量:14
  • 3何文丹,刘英志,徐圆圆,陈东.CPP-ACP在正畸治疗中防治牙面脱矿的应用[J].上海口腔医学,2010,19(2):140-143. 被引量:13
  • 4郑艾荣,陈倩倩.两种早期釉质龋保守治疗方案的临床应用对比[J].中国当代医药,2012,19(29):42-43. 被引量:2
  • 5Mehmet Akin, Faruk Ayhan Basciftci. Can white spot lesions be treated effectively [J]. Angle Orthodontist, 2012,82 (5): 770-775.
  • 6S.K. Rao, G.S. Bhat,S. Aradhya, et al. Study of the Efficacy of Toothpaste Containing Casein Phosphopeptide in the Prevention of Dental Caries: a Randomized Controlled Trial in 12- to 15-Year-Old High Caries Risk Children in Bangalore, India [J]. Caries Res, 2009, 43 t 430-435.
  • 7Chain Fredrick, Jogikalmat Krithikadatta, Mohan Abara- jithan, et al. Remineralisation of Occlusal White Spot Lesions with a Combination of 10% CPP-ACP and 0.2% Sodium Fluoride Evaluated Using Diagnodent. A Pilot Study [J]. Oral Health & Preventive Dentistry, 2013, 11(2) : 191- 196.
  • 8Anita Andersson, Kerstin Skold-Larsson, Anders Hallgren, et al. Effect of a Dental Cream Containing Amorphous Calcium Phosphate Complexes on White Spot Lesion Regression Assessed by Laser Fluorescence [J]. Oral Health & Preventive Dentistry, 2007, 5(3) : 229-233.
  • 9Ruchi Vashisht, Rajamani Indira, S Ramachandran, et al. Role of casein phosphopeptide amorphous calcium phosphate in remineralization of white spot lesions and inhibition of Streptococcus mutans [J]. J Conserv Dent, 2013,16(4) 342-346.
  • 10李淑慧,吴佩玲.酪蛋白磷酸多肽-无定形磷酸钙在口腔治疗中的研究应用[J].牙体牙髓牙周病学杂志,2011,21(10):601-603. 被引量:8

二级参考文献113

共引文献87

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部