摘要
目的:观察盆炎坤和汤对苯酚胶浆致慢性盆腔炎大鼠模型的影响。方法:雌性SD大鼠,子宫内注射苯酚胶浆造成大鼠慢性盆腔炎模型,造模2周后分组,并灌胃给予盆炎坤和汤高、中、低3个剂量(66、33、16.5g/kg),连续14d,观察大鼠体质量、子宫脏体比、子宫内膜的病理组织学改变,检测血清中超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果:造模后大鼠体质量明显降低,子宫脏体比明显增加,血清SOD水平显著下降,MDA含量明显升高,盆炎坤和汤各剂量用药后对上述指标改变均有程度不同的对抗作用,病理检查结果也表明盆炎坤和汤各剂量对子宫内膜炎症程度有一定的改善作用。结论:盆炎坤和汤对苯酚胶浆致慢性盆腔炎大鼠模型有一定的治疗作用。
Objective To investigate the changes of Penyankunhe liquor on the CPID rat model.Methods The model was established with injection of phenol mucilage.Two weeks later the rats were randomly divided into Penyankunhe liquor low dose group,medium dose group and high dose group（66g/kg、33g/kg、16.5g/kg）.After the rats were treated 14 days with corresponding medicine intragastric administration,the pathological of endometrium was used to evaluate the effects of Penyankunhe liquor.The cotent of SOD and MDA in serum were also detected.Results It was found that the ratio value of the womb to body weight of the rats increased significantly,and the levels of SOD in serum reducted while the MDA content increased significantly.It was also found that each dose of Penyankunhe liquor had different digrees of protection against the indicators change.The pathologic examination results also showed that the Penyankunhe liquor had certain improvement effect on the degree of endometrial inflammation. Conclusion Penyankunhe liquor was effective in treating CPID in experimental rats.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2014年第4期381-385,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省医学重点学科群建设项目(XKQ-010-001)
关键词
盆炎坤和汤
慢性盆腔炎
苯酚胶浆
Penyankunhe liquor
chronic pelvic inflammatory disease （CPID）
phenol mucilage
