摘要
目的探讨胰十二指肠切除联合125I粒子治疗胰头癌的效果。方法51例行胰十二指肠切除(pancreaticoduodenectomy,PD)的胰腺癌患者,其中20例行标准胰十二指肠切除术(标准PD组),31例行标准PD术联合腹膜后125I离子植入治疗(联合PD组),比较2组手术情况、组织病理情况及并发症发生率,采用Kaplan-Meier方法分析2组生存率。结果 2组手术时间、术后住院时间、脉管癌栓、神经浸润发生率、分化程度及并发症发生率差异均无统计学意义(P>0.05);标准PD组中位生存期(14个月)与术后1、2、3a生存率(66.7%、30.8%、17.1%)明显低于联合PD组(29个月、82.7%、55.4%、28.1%)(P<0.05)。结论标准胰十二指肠切除联合125I粒子治疗胰头癌可提高患者生存率。
Objective To evaluate the effect of pancreatoduodenectomy plus 125Iodine implant on pancreatic head carcinoma. Methods In 51 patients with pancreatic head carcinoma, 20 patients received pancreatoduodenectomy, and 31 received pancreatoduodenectomy plus 125Iodine implant. The operation, histopathological results and complications were compared between two groups. The survival rate was analyzed by Kaplan-Meier method. Results There were no significant differences in the operation duration, postoperative hospitalization stay, incidences of tumor emboli in vessels and perineural invasion, differentiation degree and incidence of complications between two groups （P〉0.05）. The mean survival time, and the 1-, 9.- and 3 year survival rates were 14 months, 66.7%, 30.8% and 17.1% in patients receiving pancreatoduodenectomy, significantly lower than those in the patients receiving pancreatoduodenectomy plus 125Iodine implant （29 months, and 82.7%, 55.4%, and 28.1% ） （P〈0.05）. Conclusions Pancreatoduodenectomy plus 12s Iodine implant can improve survival rates for pancreatic head carcinoma.
出处
《中华实用诊断与治疗杂志》
2014年第6期590-592,共3页
Journal of Chinese Practical Diagnosis and Therapy
