CA125、CA199、CEA联合检测在卵巢癌诊断中的应用被引量：1

下载PDF

导出

摘要目的:探讨CA125、CA199、CEA联合检测对卵巢癌诊断的价值。方法:测定63例卵巢癌、52例卵巢良性肿瘤及50例健康体检者CA125、CA199、CEA的含量。比较三组患者三种肿瘤标志物水平的差异。同时评价三种标志物联合检测较单独检测的情况。结果:卵巢癌CA125、CA199、CEA水平高于卵巢良性肿瘤和健康体检者,差异有统计学意义(P<0.05);卵巢良性肿瘤CA125水平高于健康体检者,差异有统计学意义(P<0.05)。而卵巢良性肿瘤CA199、CEA水平稍高于健康体检者,差异无统计学意义(P>0.05);卵巢癌单独及联合检测阳性率均高于卵巢良性肿瘤及健康体检者,差异有统计学意义(P<0.05)。同时联合检测阳性率高于单独检测,差异有统计学意义(P<0.05)。结论:卵巢癌CA125、CA199、CEA水平较卵巢良性肿瘤及健康体检者高。三者联合检测较单独检测卵巢癌阳性率高。进而提高卵巢癌诊断率,早期发现及治疗。

作者陈辉

机构地区湖南省长沙市第一医院病理科

出处《吉林医学》 CAS 2014年第15期3323-3323,共1页 Jilin Medical Journal

关键词 CA125 CA199 CEA 卵巢癌诊断应用

分类号 R737.31 [医药卫生—肿瘤]

引文网络
相关文献

参考文献2

1易琳,黄学梅,刘预,李雨聪,林一民,周琦.CA125、CA199、CEA联合检测在卵巢癌诊断中的应用[J].重庆医学,2012,41(32):3372-3374. 被引量：47
2黄芳.CA125、CA199与CEA联合检测对卵巢癌的诊断价值[J].广西医学,2010,32(4):424-425. 被引量：11

二级参考文献21

1陆云飞,向俾庭,曾健,廖清华,林坚,林进令.血清TSGF、CA153、CA125及CEA联合检测对乳腺癌的诊断价值[J].广西医科大学学报,2006,23(2):173-175. 被引量：32
2乐杰.妇产科学[M]第5版[M].北京：人民卫生出版社,2001.129-257.
3Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009 [J].CA Cancer J Clin, 2009,59 (4) : 225-249.
4Gubbels J,Claussen N, Kapur AK, et al. The detection, treatment and biology of epithelial ovarian cancer[J]. J O- varian Res, 2010,3 (8) : 1-11.
5Ueda Y, Enomoto T, Kimura T, et al. Serum biomarkers for early detection of gynecologic cancers [J].Cancers, 2010,2 (2) : 1312-1327.
6Donach M, Yu Y, Artioli G, et al. Combined use of bio- markers for detection of ovarian cancer in high-risk women[J].Tumour Biol,2010,31(3) :209-215.
7Yurkovetsky Z, Skates S, Lomakin A, et al. Development of a multimarker assay for early detection of ovarian canc- er[J]. Clin Oncol,2010,28(13) :2159-2166.
8Jacobs IJ,Menon U. Progress and challenges in screening for early detection of ovarian eaneer[J]. Mol Cell Pro- teomics, 2004,3 (4) :355-366.
9Robertson DN, Pruysers E,Jobling T. Inhibin as a diag- nostic marker for ovarian cancer[J]. Cancer Letters, 2007,249 (1) : 14-17.
10Kolwijek E, Thomas CMG, Bulten J, et al. Preoperative CA-125 levels in 123 patients with borderline ovarian tumors:a retrospective analysis and review of the litera- ture[J].Int J Gynecol Cancer,2009,19(8) : 1335-1338.