摘要
目的探讨乌司他丁对老年重症胰腺炎患者腹内高压及肠道黏膜屏障功能的影响。方法选取2010年1月~2013年6月该院所收治的老年重症胰腺炎患者52例,随机将患者分为对照组和乌司他丁组,每组26例。两组患者均给予常规的治疗方案,乌司他丁组患者在此基础上采用乌司他丁进行治疗。分别对两组患者临床治疗效果、治疗前后腹腔内高压以及肠黏膜屏障功能等改善情况进行比较分析。结果与对照组患者相比,乌司他丁组患者临床治疗的显效率和总有效率明显提高,分别为65.38%和96.15%,而无效率明显降低,仅为3.85%,差异有显著性（P〈0.05）。两组患者经治疗后腹腔内高压情况及肠道黏膜屏障功能较治疗前均明显改善,差异有显著性（P〈0.05）;与对照组患者治疗后相比,腹腔内高压情况及肠道黏膜屏障功能改善更为显著（P〈0.05）。结论乌司他丁能够在显著提高老年重症胰腺炎患者临床治疗效果的同时,对患者的腹内高压及肠道黏膜屏障功能也起到了积极改善作用。
【Objective】To probe into the effects of Ulinastatin in intra-abdominal pressure and intestinal mucosal barrier function for elderly patients with severe pancreatitis.【Methods】52 elderly patients with severe pancreatitis in our hospitalwere selected from January 2010 to June 2013. The patients were divided into control group and ulinastatin groups randomly. There were 26 cases in each group. The patients in two groups were given conventional treatment. The patients in Ulinastatin group were treated with ulinastatin treatment. The clinical outcomes, the improvement situation of intra-abdominal pressure and intestinal barrier function before and after treatment of the patients in two groups were compared and analysis.【Results】Compared with control group, the rates of significant efficiency and total efficiency clinical treatment for patients in ulinastatin group were increased significantly, up to 65.38% and 96.15%, and the rate of inefficiency was decreased significantly, only 3.85%, there were statistically significant（P ＆lt;0.05）. Compared with before treatment, the patients in two groups after treatment, intra-abdominal the situation of intra-abdominal pressure and intestinal barrier function were improved significantly（P ＆lt;0.05）. Compared with control group after treatment, the patients in ulinastatin group after treatment, intra-abdominal the situation of intra-abdominal pressure and intestinal barrier function were improved significantly（P ＆lt;0.05）. 【Conclusions】Ulinastatin is able to significantly improve the clinical treatment effect of elderly patients with severe pancreatitis. It also plays positive effects of improving the situation of intra-abdominal pressure and intestinal barrier function for elderly patients with severe pancreatitis.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2014年第10期92-94,共3页
China Journal of Modern Medicine
关键词
重症胰腺炎
乌司他丁
老年
腹内高压
肠道黏膜屏障功能
severe pancreatitis
Ulinastatin
elderly
intra-abdominal pressure
intestinal barrier function
