摘要
以L-谷氨酸为起始原料,经重氮化、羧基还原、羟基保护、内酯还原、脱保护基及氧化等7步反应合成了Goniothalalmin类似物的关键中间体——(S)-4-[(叔丁基二苯基甲硅烷基)氧基]-5-[(4-甲氧基苄基)氧基]戊醛(8),总收率12%。8为新化合物,其结构经1H NMR,13C NMR,IR和HR-MS表征。
A novel key intermediate of the Goniothalalmin derivatives,(S)-4-[(tert-butyldiphenylsilyl) oxy]-5-[(4-methoxybenzyl) oxy] pentanal with the total yield of 12%,was synthesized by a seven-process reaction of diazo-reaction,reduction of carboxy group,protection of hydroxy group,lactone reduction,oxidation and so on using L-glutamic acid as the starting material.The structure was characterized by 1H NMR,13C NMR,IR and HR-MS.
出处
《合成化学》
CAS
CSCD
北大核心
2014年第3期382-385,共4页
Chinese Journal of Synthetic Chemistry
基金
中央高校基本科研业务费专项资金资助项目
上海市教委科研创新项目(13ZZ047)