葡萄糖-6-磷酸异构酶抗原、抗CCP抗体、类风湿因子检测诊断早期类风湿关节炎的临床研究被引量：3

下载PDF

导出

摘要类风湿关节炎（RA）是一种常见的风湿病，对健康的主要危害是致畸致残，累及主要脏器或并发感染时可危及生命。在 RA 患者的身体中存在各种自身抗体，除了类风湿因子外，近些年葡萄糖-6-磷酸异构酶（GPI）抗原受到较多关注。国内的一些研究表明 GPI 抗原在部分 RA 患者尤其是活动的 RA 患者血清中异常升高，具有诊断和评估疾病的意义［1］。因此，我们在临床中对拟诊早期 RA 患者进行了GPI、抗 CCP 抗体、RF 等检测，进行分析和总结。

作者陈琳姜国平王晓红吕英春李慧颖付堃陈晶韩梅

机构地区吉林省人民医院血液风湿科吉林省人民医院检验科

出处《中国实验诊断学》 2014年第5期802-804,共3页 Chinese Journal of Laboratory Diagnosis

基金吉林省卫生厅医学科研基金项目(项目编号:2008Z092)

关键词葡萄糖-6-磷酸异构酶早期类风湿关节炎类风湿因子自身抗体临床研究 CCP 抗原诊断

分类号 R593.22 [医药卫生—内科学] R446.6 [医药卫生—诊断学]

引文网络
相关文献

参考文献12

1鲍春德,叶萍,陈晓翔,叶霜.血清中6-磷酸葡萄糖异构酶抗原升高在类风湿关节炎中的意义探讨[J].中华风湿病学杂志,2005,9(5):277-279. 被引量：80
2栗占国.类风湿关节炎[M].第2版(试行版).北京:人民卫生出版社,2010:76.
3Kouskoff V, Korganow AS, Duchatelle V, et al. Organ-specific dis- ease provoked by systemic autoimmunity[J]. Cell, 1996,87:81.
4Schaller M, Burtonn DR, Ditzel HJ. Autoantibodies to GPI in rheumatoid arthritis:linkage between an animal model and human disease[J]. Nat Immunol, 2001,2 : 746.
5Cha HS, Kim TJ, Kim JY, et al. Autoantibodies to glucose-6-phosphate isomerase are elevated in the synovial fliud of rheumatoid arthrifts pations[J]. Scand J Rheumatol, 2004,33: 179.
6Kassahn D, Kolb, Solomon S, et al. Few human autoimmunesera detect GPI[J]. Nat Immunol, 2002,3: 411.
7Van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, et al. Antibod- ies to eitrullinated peptide predict progressin to rheumatoid arthri- tis in pations with undifferentiated arthritis: a prospective cohort study[J]. Arthritis Rheum, 2004,50 : 709.
8钱龙,李向培,张宏,厉小梅,汪国生,单曙光,王玮.类风湿关节炎抗环瓜氨酸肽抗体的随访研究[J].中华风湿病学杂志,2005,9(9):570-572. 被引量：8
9林宁,梁淑慧.抗环瓜氨酸肽抗体在类风湿关节炎发病机制病情进展及治疗监测中的意义[J].中华风湿病学杂志,2008,12(6):418-421. 被引量：3
10刘喜德,蔡龙,李召东,张金禄.抗环瓜氨酸肽抗体与类风湿关节炎的相关性研究[J].中华风湿病学杂志,2007,11(6):361-365. 被引量：15

二级参考文献56

1周彬,朱静,刘建,龙武彬,吴晓丹,程佳,吴侗.抗环瓜氨酸肽抗体检测在类风湿关节炎中的诊断及预后意义探讨[J].中华风湿病学杂志,2004,8(6):360-362. 被引量：51
2鲍春德,叶萍,陈晓翔,叶霜.血清中6-磷酸葡萄糖异构酶抗原升高在类风湿关节炎中的意义探讨[J].中华风湿病学杂志,2005,9(5):277-279. 被引量：80
3穆荣,何菁,栗占国.环瓜氨酸多肽对类风湿关节炎T细胞激活作用的研究[J].中华风湿病学杂志,2006,10(5):273-276. 被引量：18
4Schellekens GA, Dejong BAW, Vanden Hoogen FHJ, et al. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis specific auto-antibodies. J Clin Invest, 1998, 101: 2735.
5Schellekens GA, Visser H, dejong BAW, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum, 2000. 43: 15512.
6Raptopoulou A, Sidiropoulos P, Katsouraki M, et al. Anti-citrulline antibodies in the diagnosis and prognosis of rheumatoid arthritis: evolving concepts. Crit Rev Clin Lab Sci, 2007, 44: 339-363.
7Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Int Med, 2007, 146: 797-808.
8Matsui T, Shimada K, Ozawa N, et al. Diagnostic utility of anticyclic citrullinated peptide antibodies for very early rheumatoid arthritis. J Rheumatol, 2006, 33: 2390-2397.
9Stolt P, Bengtsson C, Nordmark B, et al. Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis, 2003, 62: 835-841.
10Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum, 2006, 54: 38-46.