摘要
目的··:观察褪黑素 (melatonin,MT)对吗啡戒断小鼠前列腺及睾丸的组织学影响。方法··:设立对照组 (A)和实验组 (B、C、D) ,实验组分别皮下注射定量吗啡 ,建立吗啡依赖模型 ,A组皮下注射等量生理盐水 ,B组继续注射吗啡 ,C组自然戒断 ,D组自然戒断后给MT。实验后将前列腺及睾丸作HE染色 ,光镜观察 ,并进行图象分析。结·果·:吗啡依赖组小鼠前列腺和睾丸组织有不同程度萎缩 ;吗啡戒断组小鼠前列腺组织有明显增生 ,睾丸组织有轻度增生 ;吗啡自然戒断后给MT组小鼠前列腺和睾丸组织基本正常。结论··:MT可抑制吗啡戒断小鼠前列腺和睾丸组织的增生。
Objective: To observe the histological effect of melatonin on prostate and testis in morphine withdrawal mice. Method: A physical dependent model in mice was established by subcutaneous injection of morphine. The histological changes in prostate and testis were observed with microscope. Result: The prostate and testis in morphine dependent mice were atrophied. A multiplication of prostate could be observed in natural morphine withdrawal mice and multiplication of prostate and testis could be inhibited by melatonin. Conclusion: The multiplication of prostate in morphine withdrawal mice could be inhibited by melatonin .
出处
《中国药物依赖性杂志》
CAS
CSCD
2001年第1期36-38,42,共4页
Chinese Journal of Drug Dependence
基金
天然药物及仿生药物国家重点实验室资助
关键词
褪黑素
吗啡戒断
前列腺
睾丸
melatonin
morphine withdrawal
prostate
testis
