摘要
为观察高乌甲素超前镇痛加亚甲蓝长效止痛剂局部注射对肛肠病患者进行术后镇痛的效果，将300例拟行手术治疗的肛肠病患者随机分为A、B、C三组，各100例，镇痛方式：A组术前3h肌肉注射氢溴酸高乌甲素8mg，术后于创面局部点状注射亚甲蓝长效止痛剂（亚甲蓝20mg、2％利多卡因5ml、注射用水10ml的混合液）；B组仅术后于创面局部点状注射亚甲蓝长效止痛剂；C组仅术后口服曲马多缓释片。对比观察三组患者的术后镇痛效果。结果显示，（1）肛门疼痛VAS评分：A组患者术后6～72h几乎无痛。术后6h、24h肛门疼痛VAS评分A组均低于B、c组，P〈0．05或P〈0．01。术后72h肛门疼痛VAS评分A组与B组比较差异无统计学意义，P〉0．05；但A组、B组均明显低于C组，P〈0．01。（2）镇痛效果：A组患者术后6～72h镇痛效果均为优。术后6h、24h镇痛效果A组均明显优于B、c组，P〈0．01。术后72h镇痛效果A组与B组比较差异无统计学意义，P〉0．05；但A组、B组均明显优于C组，P〈0．01。结果表明，高乌甲素超前镇痛加亚甲蓝长效止痛剂局部注射对肛肠病患者进行术后镇痛操作简单，安全，效果满意。
In order to observe the analgesia efficacy of preemptive injection with Lappaconitine plus postoperative local injection with Methylene blue long-acting anodyne, authors divided 300 patients with anorectal diseases to be subjected to surgery into group A,B,C, 100 cases for each group; on analgesia modes, group A received intramuscular injection of 8mg Lappaconitine Hydrobromide 3hs before operation,and after operation also received local spot-like（on the wound-surface） injection of Methylene blue long-acting anodyne （Methylene blue 20mg,2% Lidocaine 5ml,and 10ml water for injection）;group B alone postoperative local spot-like injection of Methylene blue;group C alone oral Tramadol delayed-release tablets; then, the analgesia efficacies of three groups were observed and compared. As results, 1）VAS score on anus.within 6 to 72h after operation group A had no pain almostly, at 6,24h after operation VAS score of group A was lower than group B,C（ P 〈0.05 or P 〉0.05） ; at 72h there was no statistical difference between A and B（ P 0.05） ,but A and B were significantly lower than C（ P 〈0.01） ; 2）analgesia efficacies..within 6 to 72h after operation group A was excellent,at 6,24h A was singificantly superior to B,C（ P 〈0.01） ,at 72h there was no statistical difference between A and B（ P 〉0.05）,but A and B were all significantly superior to C（ P 〈0. 01）. Results show that above combination analgesia is of simple manipulation, safety and has satisfactory efficacy.
出处
《中国肛肠病杂志》
2014年第4期61-63,共3页
Chinese Journal of Coloproctology
关键词
肛肠疾病
超前镇痛
高乌甲素
局部注射
长效止痛剂
镇痛效果
Anorectal disease
Preemptive analgesia
Lappaconitine
Local injection
Long-acting anodyne Analgesia efficacy
