摘要
目的：探讨血浆铁蛋白（SF），纤维蛋白原（FIB）及D-二聚体水平和脑小血管病（SVD）的相关性。方法选取359例SVD患者，按照头颅MRI结果进一步分为腔隙性梗死组（ LI ）186例和白质疏松组（LA）173例。同时选择健康对照组146名。检测各组的SF（放免法）、FIB及D-二聚体（Clauss 法）水平。结果 SVD组SF、FIB及D-二聚体水平[（171．82±156．28）μg/L，（3．27±0．93）g/L，（1．10±1．06）mg/L]均明显高于健康对照组[（100．37±70．11）μg/L，（2．97±0．88） g/L，（0．83±0．55） mg/L]（均P＜0．05）。将SVD分为LI和LA进行比较发现，LA组各观测值[（185．22±108．55）μg/L，（3．32±0．86） g/L，（1．29±1．17）mg/L]均较LI组[（159．36±89．69）μg/L，（3．23±0．99）g/L，（1．03±0．80）mg/L]高，但差异均无统计学意义（均P＞0．05）。在校正相关因素后发现，高SF水平组（SF＞151．16μg/L）患SVD风险是低SF水平组（≤151．16μg/L）的3．44倍（OR＝3．444，95％CI为2．097～5．158，P＜0．001）。高D-二聚体水平组（＞1．02 mg/L）患SVD的风险较低D-二聚体组（≤1．02 mg/L）明显增加（OR＝1．767，95％CI为1．114～2．803，P＝0.016）。结论 SVD患者SF、FIB及D-二聚体水平高于健康人群，且SF及D-二聚体与SVD独立相关。
Objective To explore the correlation of serum ferritin （SF）,fibrinogen（FIB） and D-dimer levels in patients with small vessel disease（SVD）.Methods 359 patients with SVD were selected,including 186 patients with lacunar infarction （ LI） and 173 patients with leukoaraiosis （ LA） .176 healthy controls were enrolled in this study as control group.The SF,FIB and D-dimer concentrations were measured by radioimmunoassay method and Clauss method respectively .Results The serum levels of SF , FIB and D-dimer in SVD patients were significantly higher than those in the controls [（171.82 ±156.28）μg/L vs （100.37 ±70.11）μg/L,（3.27 ±0.93） g/L vs （2.97 ± 0.88）g/L,（1.10 ±1.06）mg/L vs （0.83 ±0.55）mg/L]（all P〈0.05）.Compared with LI subgroup,the levels of SF,FIB and D-dimer were higher in LA subgroup [（185.22 ±108.55）μg/L vs （159.36 ±89.69）μg/L,（3.32 ± 0.86）g/L vs （3.23 ±0.99）g/L,（1.29 ±1.17）mg/L vs （1.03 ±0.80）mg/L],but the differences were not signifi-cant（all P〈0.05）.Multivariate regression analysis revealed that by comparison to the reference quartile ,the odds ra-tio （95%CI） for SVD patients in the higher quartile （SF＆gt;151.16μg/L,D-Dimer＆gt;1.02 mg/L） were 3.444（95%CI=2.097-5.158,P〈0.001） and 1.767（95%CI=1.114-2.803,P=0.016）,respectively after multivariable ad-justment.Conclusion The increased levels of SF ,FIB and D-dimer are closely related with SVD .FIB and D-dimer might come to be attractive approaches to prevent the progress of SVD .
出处
《中国基层医药》
CAS
2014年第10期1463-1465,共3页
Chinese Journal of Primary Medicine and Pharmacy
