摘要
目的观察胰岛素泵治疗非肥胖2型糖尿病合并OSAHS的疗效。方法将非肥胖2型糖尿病合并OSAHS的患者80例分为胰岛素泵组和口服药组治疗4周。治疗前后均进行多导睡眠仪检查,观察两组患者治疗前后的胰岛素抵抗指数(HOMA-IR)、呼吸参数等的变化。结果胰岛素泵组治疗后的HOMA-IR、低通气指数、最低血氧饱和度均优于口服药组,分别为(12.1±6.4)vs.(17.3±9.5)、(5.2±2.1)vs.(8.9±3.3)、(89.6±5.9)%vs.(82.8±6.2)%,P均<0.05。结论胰岛素泵治疗有助于改善非肥胖2型糖尿病合并OSAHS患者的胰岛素抵抗及呼吸紊乱。
Objective To observe the effect of insulin pump on nonobese type 2 diabetes combined with obstructive sleep apnea-hypopnea syndrome （OSAHS）. Methods Eighty nonobese type 2 diabetes patients with OSAHS were divided into insulin pump group （n=40）and oral medicine group （n=40）. Both groups received 4 weeks treatment. Insulin level were tested and insulin resistance index （HOMA-IR）were evaluated before and after treatment. Respiratory disturbance of those patients were also analyzed by sleep detectors. Results After 4 weeks of treatment,HOMA-IR,hypopnea index and the lowest degree of blood oxygen saturation in insulin pump group were significantly improved than those of oral medicine group （1 2.1 ±6.4 vs.17.3 ±9.5,5.2 ±2.1vs.8.9 ±3.3、 （89.6 ±5.9）% vs. （82.8 ±6.2）%,respectively）（P〈0.05）.Conclusions Insulin pump might improve the insulin resistance status and respiratory disturbance of patients with nonobese type 2 diabetes combined with OSAHS.
出处
《新医学》
2014年第5期324-327,共4页
Journal of New Medicine
关键词
2型糖尿病
非肥胖
阻塞性睡眠呼吸暂停
胰岛素泵
Type 2 diabetes
Non-obese
Obstructive sleep apnea-hypopnea syndrome
Insulin pump
