摘要
目的 了解高脂血症患者经过 3个月以上恒定治疗后 ,各项血脂的变化及其达到规定目标水平的情况。方法 从北京、广州及上海 17家医院 10 0 0例高脂血症患者的病历中收集所需信息数据 ,进行整理分析。结果 患者治疗前各项血脂平均值为总胆固醇 6 5 5mmol/L ,低密度脂蛋白胆固醇 4 10mmol/L ,甘油三酯 2 89mmol/L ,高密度脂蛋白胆固醇 1 2 7mmol/L ,治疗后分别为 5 5 6、3 40、2 11和 1 32mmol/L ,前三者有显著降低。按我国“血脂异常防治建议”的目标 ,达到目标水平的百分率分别为总胆固醇 2 7 4% ,低密度脂蛋白胆固醇 31 6 % ,甘油三酯 42 9% ,三项全部达标者仅10 1%。所用调脂药物中他汀类占 5 9 0 % ,贝特类 2 3 7% ,中成药 11 4%。结论 目前在接受药物治疗的高脂血症患者中 ,血脂水平大多数未达到要求的目标 ,今后应给予足够剂量的已证明有效的药物 。
Objective To assess the changes in blood lipids and the status of attaining goals of therapy among patients receiving drugs for treatment of blood lipids disorders for 3 months or longer. Methods Data collected for analysis were from records of 1 000 patients with elevated blood lipids from 17 hospitals of Beijing, Shanghai and Guangzhou. Results Mean levels of blood lipids were: total cholesterol (TC) 6.55 mmol/L, low density lipoprotein cholesterol (LDL C) 4.10 mmol/L, triglycerides (TG) 2.89 mmol/L, and high density lipoprotein cholesterol (HDL C) 1.27 mmol/L before treatment and 5.56, 3.40, 2.11 and 1.32 mmol/L respectively after treatment, showing significant lowering for the first three lipids. Cases attaining the goals of therapy recommended by China's Guidelines for Control of Blood Lipids Disorders constituted for TC 27.4%, LDL C 31.6%, TG 42.9%, and for all three together 10.1%. Drugs used included statins 59.0%, fibrates 23.7%, and herb drugs 11.4%. Conclusion Currently the majority of patients receiving drug therapy for lipid disorders did not attain levels of recommended goals. Adequate doses of drugs with proven efficacy should be used to ensure definite clinical benefits to patients.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2001年第1期15-17,共3页
Chinese Journal of Cardiology
关键词
血脂异常
高脂血症
治疗
调查
Blood lipids disorders
Hyperlipidemia
Survey
