摘要
目的:研究对妊娠期合并甲状腺亚临床功能减退患者采用甲状腺素替代疗法的时机和剂量规律,为临床上优生优育提供参考建议。方法:回顾性分析该院内分泌科收治的妊娠合并甲状腺亚临床功能减退的孕妇36例,分析按照不同剂量在不同时间给药前后患者甲状腺激素FT4、促甲状腺激素TSH指标变化情况。结果:甲状腺激素的替代量均明显高于入组时的使用量,FT4在治疗后每一个月与入组时比较均明显高于入组时,TSH在治疗后每一个月与入组时比较均明显低于入组时的水平,且差异均具有统计学意义(P<0.05);分别比较入组时和孕9月时的血清总胆固醇(CHO)、三酰甘油(TG)、瘦素的变化,经过替代治疗3种指标均明显下降,且差异具有统计学意义(P<0.05)。结论:妊娠早期进行甲状腺功能检查,对有甲状腺功能减退的妊娠妇女及时采取甲状腺激素替代疗法将可以有效地调节机体甲状腺素水平,达到优生优育的目的。
Objective： To research the opportunity and dose of law of thyroid hormone replacement therapy for pregnant patients complicated with subclinical thyroid hypofunction, provide reference for clinical eugenics. Methods： Thirty - six pregnant patients complicated with subclinical thyroid hypofunction treated in Endocrinology Department of the hospital were analyzed retrospectively; the changes of free thyroxine and thyroid stimulating hormone （TSH） levels before and after treatment with different doses at different time points were analyzed. Results ： The dose of thyroid hormone replacement was statistically significantly higher than that of grouping （ P 〈 0.05 ） ; the levels of free thyroxine in every month after treatment were statistically significantly higher than that of grouping （ P 〈 0. 05 ） ; the levels of TSH in every month after treatment were statistically significantly lower than that of grouping （ P 〈 0.05 ） ; the levels of serum total cholesterol, triglyceride and leptin at the ninth gestational month were statistically significantly lower than that of grouping （ P 〈 0. 05 ） . Conclusion ： Thyroid function tests during the first trimester of pregnancy and timely thyroid hormone replacement therapy for pregnant patients complicated with subclinical thyroid hypofunction can effectively regulate the level of thyroid hormone and achieve the goal of eugenics.
出处
《中国妇幼保健》
CAS
北大核心
2014年第17期2682-2684,共3页
Maternal and Child Health Care of China
基金
河南省南阳市卫生局科研项目〔2012AA200B03〕
