摘要
目的：宫内TORCH感染与新生儿神经行为发育的相关性。方法：选取2011年10月-2013年10月1650例胎龄为37—42周的新生儿，以检查TORCH系列抗体一项或多项IgM（＋），母亲在产前筛查或产时监测TORCH系列抗体一项或多项同种病原体IgM（＋）的新生儿作为感染组，对照组为同期检查母亲及新生儿脐血（或外周血）TORCH感染均为阴性的新生儿110例，所有新生儿均在出生后48～72h、12～14天、26—28天测查NBNA评分。结果：新生儿弓形虫（TOX）、风疹病毒（RUV）、巨细胞病毒（CMV）、疱疹病毒（HSV）感染率比较差异有统计学意义（P〈0．05），其中CMV感染率最高（1．58％），其次为RUV（0．73％）、HSV（0．36％）、TOX（0．18％）；各时间段RUV和CMV感染组新生儿NBNA评分均低于对照组（P〈0．05），TOX和HSV感染组新生儿NBNA评分与对照组相比无统计学差异（P〉0．05），各感染组间NBNA评分无明显差异（P〉0．05）。同一感染组新生儿NBNA评分在3个时间段比较差异均有统计学意义（P〈0．05）。结论：宫内TORCH感染会影响新生儿神经行为的发育，进行医学干预将有助于改善病情。
Objective： To analyze the correlation between intrauterine TORCH infection of pregnant women and neonatal behavioral neurological development. Methods ： A total of 1 650 neonates of 37 - 42 weeks were selected from October 2011 to October 2013 ; the neonates with at least one positive result of TORCH IgM or with at least one positive result of maternal TORCH antibody during prenatal screening or intrapartum monitoring were selected as infection group; 110 neonates with negative result of maternal and neonatal umbilical cord （or peripheral blood） TORCH infection during the same period were selected as control group; NBNA score was conducted among all the neonates at 48 - 72 hours, 12 - 14 days and 26 - 28 days after birth. Results： There were statistically significant differences in infection rates of neonatal Toxoplasma gondii （TOX）, rubella virus （RUV）, cytomegalovirus （CMV） and herpes virus （HSV） between the two groups （P 〈0. 05）, the infection rate of CMV was the highest （ 1.58% ）, followed by RUV （0. 73% ）, HSV （0. 36% ） and TOX （0. 18% ） ; NBNA scores of RUV and CMV during different time periods in infection group were statistically significantly lower than those in control group （ P 〈 0. 05）, there was no statistically significant difference in NBNA scores of TOX and HSV between infection group and control group （ P 〉 0. 05）, there was no statistically significant difference in NBNA score among different infection subgroups （P 〉 0. 05） . In the same infection group, there was statistically significant difference in NBNA score among three time periods （ P 〈 0.05 ） . Conclusion ： TORCH intrauterine infection can affect neonatal neurobehavioral development, medical intervention will help to improve the condition.
出处
《中国妇幼保健》
CAS
北大核心
2014年第17期2751-2753,共3页
Maternal and Child Health Care of China
