摘要
目的：探讨尿激酶、肝素和阿司匹林联合治疗下肢深静脉血栓形成（ＬＥＤＶＴ）的安全性和有效性．方法：下肢深静脉血栓形成患者１７例，平均病程５周（其中１０例患者病程２周～３周之间）．静脉造影确诊后即予尿激酶（ＵＫ）５０ 万 Ｕ１０ｍｉｎ内推入，随后 １ｈ内静滴 １００ 万 Ｕ，第 ２ 天～第 ３天每天静滴 １００万 Ｕ，第 ４天～第 １４天每天静滴 ２５万Ｕ－５０万Ｕ．同时每天予肝素钙５０ｍｇ皮下注射１次／１２ｈ、阿司匹林７５ｍｇ－１２５ｍｇ口服１次／日。结果：血栓完全溶解４例（２３．５３％），部分溶解件再通 ６例（３５．２９％），部分溶解伴未再通 ５例（２９．４１％），血栓无变化２例（１１．７７％），未见血栓进展病例。８例肝素注射部位出血。结论：采用尿激酶联合肝素和阿司匹林治疗ＬＥＤＶＴ具有较好的安全性和一定的有效性．
To investigate the safety and efficacy of urokinase (UK), heparin and aspirin in the treatment of low extremity deep venous thrombosis (LEDVT). Methods: 17 cases of patients with LEDVT were enrolled in the study. The mean duration of illness was 5 weeks and 10 among them were within 10 min and 1 million nits was followed in step one hour 1 million units were given in 2nd and 3rd days within an hour. 0.25 or 0.5 million units were infused within an hour from 4th to 14th. In the meantime heparin and aspirin were given. Results: 4 cases were completely lysed (23.54%), 6 cases were partially lysed with reperfusion (35.29%), 5 cases were partially lysed with non-reperfusion (29.41%) and 2 cases were unchanged. 8 cases had mild hemorrhage in the local site of heparin injection. Conclusion: UK associated with heparin and aspirin in the treatment of LEDVT had relatively safety and certainly efficacy.
出处
《伤残医学杂志》
2000年第4期23-26,共4页
Medical Journal of Trauma and Disability
基金
上海市首批医苑新星培训计划的资助
