摘要
目的分析米索前列醇、欣普贝生及COOK宫颈扩张双球囊促宫颈成熟的特点，探讨足月妊娠适宜的引产措施。方法将91例有引产指征、宫颈Bishop评分〈6分的足月妊娠初产妇随机分为米索前列醇组（31例）、COOK球囊组（28例）、欣普贝生组（32例），观察各组孕妇宫颈Bishop评分、宫缩情况、产程时间、分娩方式及母胎并发症。结果欣普贝生组及COOK球囊组促宫颈成熟显效率分别为78．6％、75．O％，明显优于米索前列醇组（22．6％），但欣普贝生组强直性宫缩、胎盘早剥的发生率高于COOK球囊组（P〈0．05）。欣普贝生组与COOK球囊组剖宫产率比较差异无统计学意义（P〉0．05），但均低于米索前列醇组（P〈0．05）。三组病例新生儿Apgar评分、脐动脉pH值比较差异无统计学意义（P〉0．05）。结论小剂量米索前列醇口服给药促宫颈成熟作用较弱，但给药途径方便，价格便宜，对于经济状况低下人群可考虑使用。欣普贝生诱导宫颈成熟效果明显，但可出现强直性宫缩、第二产程过快、胎盘早剥等不良反应。COOK球囊促宫颈成熟作用温和、不良反应少，是除米索前列醇及欣普贝生外另一种可供选择的促宫颈成熟方法。
Objective To evaluate the effectiveness and safety of Misoprostol, Prostaglandin E2 suppositories and COOK balloon catheter in induction of labor at term. Methods 91 women of full-term pregnancy with indications of induced abortion, and cervical Bishop score 〈6 were randomly divided into Misoprostol group （31 cases）, Prostaglandin E2 group （32 cases） and COOK balloon group （28 women）. The improvement of cervical conditions was compared before and after the application. The uterine contraction, labor time, fetus delivery method, situation of maternal and newborn were determined. Results The obvious effective rate in Prostaglandin E2 suppositories was 78.6%, in COOK balloon group it was 75.0%, both were significantly higher than those in Misoprostol group. However, the side effect such as placental abruption was found in Prostaglandin E2 group. The cesarean section ratios in the COOK balloon group and the prostaglandin E2 group were much the same, but both were lower than those of the Misoprostol group. Conclusion Although the efficacy of Misoprostol is much weak, it is convenient and cheap. COOK balloon catheter method is the same as prostaglandin E2 in induced labor at term, it is safe and has less side effect.
出处
《国际医药卫生导报》
2014年第11期1540-1543,共4页
International Medicine and Health Guidance News
