摘要
目的探讨孟鲁司特钠联合布地奈德在小儿咳嗽变异性哮喘治疗中的临床疗效。方法选取201a年3月～2013年7月来梅州市平远县人民医院儿科门诊及住院治疗的咳嗽变异性哮喘患儿96例，随机均分为对照组（n=46）和观察组（n=50）。对照组应用布地奈德雾化吸入加酮替酚进行治疗，口服酮替酚片，1mg／次，2次／d；观察组应用布地奈德雾化吸入加孟鲁司特钠，口服孟鲁司特钠，6岁以下患儿服用4mg，6岁以上患者5mg，患儿睡前服用，1次／（片·d）。连续治疗3个月后分析其疗效。结果观察组的总有效率为920％，明显高于对照组的总有效率80．4％；观察组临床症状改善时间均明显优于对照组；观察组总复发率8o％，明显低于对照组总复发率17．4％，差异均有统计学意义（均P〈0.05）。结论孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘临床疗效显著，可明显改善患儿临床症状、降低复发率。
Objective To investigate the clinical efficacy of montelukast combined with budesonide on children with cough variant asthma. Methods From 2012 March to July 2013 in the hospital outpatient department of pediatrics,96 cases with cough variant asthma were randomly divided into 46 cases in the control group （inhaled budesonide plus ketotifen treatment） and the observation group of 50 cases with aerosol inhalation of budesonide combined with montelukast sodium. The application of the control group inhaled budesonide plus ketotifen treatment, oral ketotifen tablets, 1 mg/times, 2 times/d; the observation group with inhaled budesonide combined with montelukast sodium, oral montelukast in children below 6 years old, taking 4 rag, patients over 6 years of age in children with 5 mg, before bedtime, 1 times / tablet/d.The curative effect of continuous 3 months after treatment was analyzed. Results The total effective rate of observation group was 92.0%, which was significantly higher than that in the control group（80.4%）; the clinical symptom improvement time was significantly better than the control group; the total relapse rate in the observation group was 8.0%, which was significantly lower than the control group 17.4%, the difference was significant （P〈 0.05）. Conclusion Montelukast combined with budesonide in treatment of children with cough variant asthma has significantly clinical effects, can obvious improve clinical symptoms, reduce the recurrence rate.
出处
《当代医学》
2014年第17期68-69,共2页
Contemporary Medicine
