摘要
目的分析癌胚抗原(CEA)水平联合miR-17-3p在结肠癌诊断中的意义。方法收集2011年1月—2013年1月在本院接受住院治疗的结肠癌患者80例(观察组)的临床资料,另选取70例健康体检者作为对照组,分析2组炎症指标、肿瘤标记物的差异,并分别对CEA水平、miR-17-3p、CEA联合miR-17-3p对结肠癌的诊断意义行ROC曲线分析。结果 2组的C-反应蛋白(CRP)、血沉(ESR)和血清白介素6(IL-6)水平比较差异均无统计学意义(P均>0.05);观察组的CEA、CA19-9、CA125和miR-17-3p相对表达量均显著高于对照组(P均<0.01);ROC曲线分析。结果提示:CEA联合miR-17-3p对结肠癌的诊断敏感性为91.21%,特异性为91.35%,曲线下面积0.949,优于CEA或miR-17-3p单独对结肠癌的诊断意义。结论CEA联合miR-17-3p对结肠癌的诊断敏感性和特异性均优于CEA或miR-17-3p单独的诊断意义。
Objective To explore the significance of CEA and miR-17-3p in the diagnosis of colon carcinoma. Methods 80 patients with colon carcinoma were designed as observation group, and 70 people with healthy examination were designed as control group. Inflammatory indicators and tumor markers were compared between two groups. Results There were no significant differences of CRP, ESR and IL-6 levels between two groups. Levels of CEA, CA19-9, CA125 and miR-17-3p in observation group were significantly higher than the control group. Sensibility, specificity and ROC of CEA combined with miR-17-3p in diagnosis of colorectal cancer were 91.21% , 91.35% and 0.949 respectively, which were significantly better than simple application of CEA or miR-17-3p. Conclusion Sensibility and specificity of CEA combined with miR-17-3p in diagnosis of colorectal cancer were better than simple application of CEA or miR-17-3p.
出处
《实用临床医药杂志》
CAS
2014年第7期30-32,共3页
Journal of Clinical Medicine in Practice
