摘要
目的观察补肾化瘀方联合达英-35治疗多囊卵巢综合征(PCOS)的临床疗效,并探讨其对血清单核细胞趋化蛋白-1(MCP-1)及血脂的影响。方法本院2008年7月—2012年4月住院治疗的55例PCOS患者随机分为2组,对照组(n=27例)仅采用达英-35治疗,观察组(n=28例)采用补肾化瘀方和达英-35联合治疗,观察和比较2组患者治疗前后MCP-1、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)水平的变化,以及各组临床疗效和不良反应。结果观察组治疗总有效率(82.1%)明显高于对照组(66.7%),P<0.05;2组患者治疗后血清MCP-1、TC、TG水平较治疗前均明显下降(P<0.05),而HDL-C较治疗前明显升高(P<0.05),且观察组各指标改善程度明显优于对照组(P<0.05);2组治疗过程中均未出现严重不良反应。结论补肾化瘀方联合达英-35治疗PCOS疗效显著,其作用机制可能为抑制MCP-1的分泌,降低血脂而取得良好的临床疗效。
Objective To observe the clinical effect of Bushen Huayu decoction combined with diane-35 on the treatment of patients with polycystic ovary syndrome （PCOS） and explore its influence on serum MCP-1 level and blood lipids. Methods 55 patients with PCOS were randomly divided into the control group （n = 27, treated with diane -35） and observation group （ n = 28, treated with Bushen Huayu decoction and diane-35）. Levels of MCP-1, TC, TG and HDL-C before and after treatment were observed and compared, and the clinical efficacy and adverse reactions were observed as well. Results Total effective rate of observation group was 82.1%, which was significantly higher than 66.7% of control group （P〈0.05）. Levels of serum MCP-1, TC, TG decreased significantly after treatment in both groups （P 〈 0.05 ）, while HDL-C increased signifi-cantly （P 〈 0.05）. Improvement of all the indexes in the observation group were significantly better than those of control group （P 〈 0.05 ）. No severe adverse reactions were observed in both groups. Conclusion Bushen Huayu decoction combined with diane-35 can effectively inhabit the secretion of MCP-1 and reduce blood lipid in patients with PCOS.
出处
《实用临床医药杂志》
CAS
2014年第7期48-50,共3页
Journal of Clinical Medicine in Practice
