摘要
目的 探讨脑组织在创伤、出血、缺血等病理情况下单胺递质的变化及其意义。方法 选取原发脑干损伤患者，伤后6～12h内采集患者肘静脉血及腰穿取脑脊液，之后1周内每天采集1次,1周后每周采集2次,到清醒或死亡时止。以Miller′s的荧光分光法检测脑干损伤的患者血液及脑脊液中单胺递质──5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)，分析脑干损伤程度与单胺递质浓度变化的关系。结果 急性颅脑创伤后，患者血浆和脑脊液中NE、DA含量明显升高，伤后病情逐渐好转者第3天达到高峰，然后逐渐下降至正常水平;死亡病例首次值明显升高，下降缓慢;但伤情极重者升高后迅速下降。结论 单胺递质浓度变化与脑干损伤程度呈正相关，与预后关系密切。
Objective To study monoamine neurotransmitter obviously changes in cerebral damage、ischemia and hemorrhage. Methods We reported the changes by means of flurospectrophotometry after brain stem injury on selected patients , and then analyzed the relationship between the changes and the prognosis. Results It showed that 5 HT、 NE、 DA increased apparently after brain stem injury , then drop to the normal level as fast as reinvigoration . The exception to this rule is for severe brain stem injury in which neurotransmitter drops fastly soon after increasing. Conclusion It suggests that we can predict the prognosis by the changes of monoamine neurotransmitter.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2001年第1期27-28,共2页
Journal of Apoplexy and Nervous Diseases
