期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

精神分裂症的药物联合治疗 被引量：12

原文传递
导出
摘要 抗精神病药的联合用药问题尚未取得公认的见解，几乎所有临床治疗指南均推荐单一药物治疗。但是为了提高治疗精神分裂症的疗效，改善精神分裂症残留的阳性症状、阴性症状、认知功能损害、抑郁症状、敌对攻击症状或其他诸如强迫和焦虑等症状，在临床实践中有许多患者接受了联合用药。对我国10省市41所精神病专科医院或综合医院精神科的5898例精神分裂症住院和门诊患者的调查结果表明，联合使用2种以上抗精神病药的比例高达26．1％。虽然联合治疗不推荐为常规一线治疗方法，但一些临床研究结果显示药物联合治疗可以使许多患者获益，多种抗精神病药联合治疗或抗精神病药和其他药物联合治疗受到关注。
作者 梅其一
机构地区 苏州大学附属广济医院精神科
出处 《中华精神科杂志》 CAS CSCD 北大核心 2014年第3期175-177,共3页 Chinese Journal of Psychiatry
关键词 药物联合治疗 精神分裂症 抗精神病药 精神病专科医院 单一药物治疗 临床治疗指南 阳性症状 认知功能损害
分类号 R749.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献18

  • 1张云淑,司天梅,栗克清.2006年我国十省市抗精神病药联合用药情况调查及其影响因素分析[J].中华精神科杂志,2012,45(4):207-212. 被引量：26
  • 2Shiloh R, Zemishlany Z, Aizenberg D, et al. Sulpiride augmentation in people with schizophrenia partially responsive to elozapine : a double-blind, placebo-controlled study [ J ]. Br J Psychiatry, 1997,171:569-573.
  • 3Kreinin A, Novitski D, Weizman A. Amisulpride treatment of clozapine induced hypersalivation in schizophrenia patients: a randomized, double-blind, placebo-controlled cross-over study [ J]. Int Clin Psychopharmaeol, 2006, 21:99-103.
  • 4Josiassen RC, Joseph A, Kohegyi E, et al. Clozapine augmented with rispefidone in the treatment of schizophrenia:a randomized, double-blind, placebo-controlled trial [ J ]. Am J Psychiatry, 2005, 162 : 130-136.
  • 5Lerner V, Chudakova B, Kravets S, et al. Combined use of risperidone and olanzapine in the treatment of patients with resistant schizophrenia : a preliminary case series report [ J ]. Clin Neuropharmaeol ,2000, 23:284-286.
  • 6Shim JC, Shin JG, Kelly DL, et al. Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsyehotic-iuduced hyperprolactinemia: a placebo-controlled trial [ J ]. Am J Psychiatry, 2007,164 : 1404-1410.
  • 7Casey DE, Daniel DG, Wassef AA, et al. Effect of divalproex combined with olanzapine or risperidone in patients with an acute exacerbation of schizophrenia [ J ]. Neuropsychopharmacology, 2003, 28 : 182-192.
  • 8Kirli S, Caliskan M. A comparative study of sertraline versus imipramine in postpsychotic depressive disorder of schizophrenia[J] Schizophr Res, 1998,33:103-111.
  • 9Matthews JD, Bottonari KA, Polania LM, et al. An open study of olanzapine and fluoxetine for psychotic major depressive disorder: interim analyse[ J]. J Clin Psychiatry, 2002, 63 : 1164-1170.
  • 10Whitehead C, Moss S, Cardno A, et al. Antidepressants for people with both schizophrenia and depression [ J ]. Cochrane Database Syst Rev, 2002, CD002305.

二级参考文献22

  • 1司天梅,舒良,于欣,马崔,王高华,白培深,刘协和,纪丽萍,师建国,陈宪生,梅其一,栗克清,张鸿燕,马弘.10省市抗精神病药使用现况的调查[J].中华精神科杂志,2004,37(3):152-155. 被引量：95
  • 2舒良主编.精神分裂症防治指南.北京:北京大学医学出版社.2007:127
  • 3McGrath J, Saha S, Chant D, et al. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol Rev, 2008, 30:67-76.
  • 4Lehman AF, Lieberman JA, Dixon LB, et al. Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry, 2004, 161 ( 2 Suppl) : 1-56.
  • 5Lehman AF, Kreyenbuhl J, Buchanan RW, et al. The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2003. Schizophr Bull, 2004, 30:193-217.
  • 6Correll CU, Rummel-Kluge C, Corves C, et al. Antipsychotic combinations vs monotherapy in schizophrenia: a meta-analysis of randomized controlled trials. Schizophr Bull, 2009, 35:443-457.
  • 7McCue RE, Waheed R, Urcuyo L. Polypharmacy in patients with schizophrenia. J Clin Psychiatry, 2003, 64:984-989.
  • 8Ponto T, Ismail NI, Abdul Majeed AB, et al. A prospective study on the pattern of medication use for schizophrenia in the outpatient pharmacy department, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia. Methods Find Exp Clin Pharmacol,2010,32: 427-432.
  • 9Stahl SM, Grady MM. A critical review of atypical antipsychotic utilization : comparing monotherapy with polypharmaey and augmentation. Curt Med Chem,2004,11:313-327.
  • 10Royal Australian and New Zealand College of Psychiatrists Clinical Practice Guidelines Team for the Treatment of Schizophrenia and Related Disorders. Royal Australian and New Zealand college of psychiatrists clinical practice guidelines for the treatment of schizophrenia and related disorders. Aust N Z J Psychiatry,2005, 39(1-2) :1-30.

共引文献25

同被引文献134

  • 1崔明伟.抗精神分裂症药物的临床研究进展[J].医学信息（医学与计算机应用）,2016,29(28):43-43. 被引量：2
  • 2龙茂远,韦伟香,黄江,李文峰,王骏,彭国军.利培酮治疗难治性精神分裂症的效果[J].中文科技期刊数据库（全文版）医药卫生,2019(1):61-61. 被引量：2
  • 3杨忠,潘凤英,尹建兵,宋静波,谭文钟.国产和进口奥氮平治疗首发精神分裂症的疗效分析[J].神经疾病与精神卫生,2006,6(5):345-346. 被引量：3
  • 4孟月兰.奥氮平与氯氮平治疗精神分裂症对照研究[J].临床心身疾病杂志,2007,13(6):497-499. 被引量：5
  • 5HORI H, YOSHIMURA R, KATSUKI A, et al. The cognitive profile of aripiprazole differs from that of other atypical antip- sychotics in schizophrenia patients[ J ]. J Psychiatr Res,2012, 46(6) :757-761.
  • 6张群.基于齐拉西酮辅助治疗伴发抑郁症状精神分裂症的120例分析[J].中国保健营养(上旬刊),2014,24(5):2410-2411.
  • 7Citrome L.Treatment-resistant schizophrenia:what can we do about it?[J].Curr Psychiatry,2011,10(6):52-59.
  • 8Correll CU,Gallego JA.Antipsychotic polypharmacy:a comprehensive evaluation of relevant correlates of a long-standing clinical practice[J].Psychiatr Clin North Am,2012,35(3):661-681.
  • 9Singh SP,Singh V,Kar N,et al.Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia:a meta-analysis[J].Br J Psychiatry,2010,197(3):174-179.
  • 10Kantrowitz JT,Javitt DC.Thinking glutamatergically changing concepts of schizophrenia based upon changing neurochemical models[J].Clin Schizophr Relat Psychoses,2010,4(3):189-200.

引证文献12

二级引证文献65

中华精神科杂志
2014年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部