摘要
目的探讨雾化吸入布地奈德混悬液治疗小儿急性喉炎的临床疗效,以期能为小儿急性喉炎的治疗提供参考。方法选取78例小儿急性喉炎患儿随机分为观察组与对照组各39例,在常规治疗基础上对照组给予地塞米松2 mg+生理盐水2 ml雾化吸入治疗,观察组给予布地奈德混悬液2 mg+生理盐水2 ml雾化吸入治疗。观察两组患儿的临床症状改善程度、治疗前及治疗3 d时炎性因子白细胞介素-4(IL-4)、白细胞介素-8(IL-8)的变化,评价其治疗效果。结果对照组患儿咳嗽消失时间、喉鸣消失时间、声嘶消失时间、呼吸困难消失时间及住院时间明显长于观察组(P<0.05);IL-4、IL-8水平观察组较对照组下降更为明显(P<0.05),对照组显效率、有效率、无效率分别为64.20%、30.77%、5.13%,观察组为82.05%、17.95%、0,观察组疗效明显优于对照组(P<0.05)。结论布地奈德混悬液雾化吸入治疗小儿急性喉炎能快速减轻患儿临床症状,减轻局部炎症反应,疗效明显优于地塞米松雾化吸入治疗。
Objective To investigate the efficacy of nebulized budesonide in the treatment of children with acute laryngitis. Methods Seventy eight children with acute laryngitis were randomly divided into observation group and control group,with 39 cases in each group. Patients in the control group were treated with dexamethasone 2mg plus saline 2ml inhalation, and observation group received budesonide 2 mg plus saline 2 ml inhalation. Degree of clin-ical improvement was observed, and inflammatory cytokines interleukin-4 （IL-4）, interleukin-8 （IL-8） changes were detected before treatment and after 3 days treatment. Results Cough disappearance time, throat wheezing sound dis-appearance time, hoarseness disappearance time, breathing difficulties disappear time and length of stay in the control group was significantly longer than those in the observation group （P〈0.05）;IL-4 and IL-8 levels decreased more sig-nificantly in observation group than those in the control group （P〈0.05）. The efficient, effective and ineffective rates in the control group were 64.20%, 30.77%and 5.13%, respectively, however, in the observation group was 82.05%, 17.95%, 0.00%, respectively, with significant difference （P〈0.05）. Conclusion Budesonide inhalation can quickly relieve symptoms, reduce the local inflammatory response in the treatment of pediatric patients with acute laryngitis.
出处
《海南医学》
CAS
2014年第10期1508-1510,共3页
Hainan Medical Journal
关键词
急性喉炎
布地奈德
儿童
地塞米松
Acute laryngitis
Budesonide
Children
Dexamethasone
