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抗凋亡转录因子在机体损伤及肿瘤中的研究进展

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摘要 抗凋亡转录因子(AATF)作为一种RNA聚合酶Ⅱ结合蛋白,在真核生物进化过程中均高度保守.在机体遭受应激或慢性损伤时,其通过激活监测点激酶对基因转录及细胞周期进行调控,以维持内环境的稳态.同时,AATF通过发挥抗凋亡或抑制细胞增殖作用,在肿瘤发生发展过程中有重要意义.笔者拟就在机体损伤过程中AATF与相关因子或蛋白间的作用机制,以及AATF在肿瘤中的研究进展进行综述如下.
出处 《国际输血及血液学杂志》 CAS 2014年第3期271-275,共5页 International Journal of Blood Transfusion and Hematology
基金 国家自然科学基金(81100349) 江苏省“六大人才高峰”项目(2011-WS-067) 徐州医学院振兴计划项目
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