摘要
目的研究3.0TMRI动态对比增强定量参数对中央区前列腺癌的诊断价值。方法回顾性分析采用3.0T MRI扫描仪进行前列腺动态对比增强MRI检查的39例前列腺中央区病变患者资料,患者均在MRI检查后1周内经手术或穿刺病理证实诊断。分别测量中央区病灶与非病灶区的定量血流动力学参数,包括容量转移常数(volume transfer constant,Ktrans)和血管外细胞外间隙容积比(extravascular extracellular space distribute volume per unit tissue volume,Ve)。采用单因素方差分析比较中央区前列腺癌、良性增生与非病灶区的组间差异,受试者特性曲线(receiVer operating characteristic curVe,ROC)分析定量参数诊断中央区前列腺癌与良性增生的敏感度、特异度。结果中央区前列腺癌(n=17)的Ktrans和Ve均值分别为(13.09±2.55)min-1和(4.57±0.81);良性增生(n=22)的Ktrans和Ve均值分别为(8.79±1.15)min-1和(5.14±1.02);非病灶区(n=29)的Ktrans和Ve均值分别为(5.34±0.98)min-1和(4.23±0.78)。中央区前列腺癌、良性增生与非病灶区组间Ktrans的差异有统计学意义(F值为4.271,P值<0.05),Ve的差异无统计学意义(F值为0.553,P值>0.05)。以最大约登指数为最佳诊断切点值,Ktrans和Ve判断中央区前列腺癌与良性增生的的敏感度分别为73.4%和54.3%;特异度分别为82.7%和47.9%。结论 3.0T MRI动态对比增强定量血流动力学参数Ktrans对中央区前列腺癌与良性增生的鉴别诊断具有很高的诊断价值,但Ve没有太大意义。
Objective To evaluate the value of quantitative parameters of Dynamic Contrast-Enhanced MRI （DCE MRI） in the diagnosis of central zone prostate cancer .Methods This retrospective study included 39 patients with prostate le-sion in central zone conformed by biopsy or surgical pathology in one week after they underwent DCE MRI by using 3 .0 T whole-body MR scanner .Quantitation of the pharmacokinetic parameters of prostate lesion and non-lesion area in central zone were measured including volume transfer constant （Ktrans ） ,extravascular extracellular space distribute volume per u-nit tissue volume （Ve ） .One-way ANOVA and receiver operating characteristic curve （ROC） analysis were used to com-pare the differences of prostate cancer ,benign hyperplasia and normal tissue of non-lesion area in central zone .Results The mean Ktrans and Ve of the prostate cancer in central zone （n=17） were （13 .09 ± 2 .55） min-1 and （4 .57 ± 0 .81） ,while （8.79 ± 1 .15） min-1 and （5 .14 ± 1 .02） for benign hyperplasia （n=22） and （5 .34 ± 0 .98） min-1 and （4 .23 ± 0 .78） for nor-mal tissue of non-lesion area in central zone （n=29） ,respectively .There were significant differences between central zone prostate cancer ,benign hyperplasia and normal tissue of non-lesion area in Ktrans （ F =4 .271 ,P ＆lt;0 .05） .There were no significant differences between central zone prostate cancer ,benign hyperplasia and normal tissue of non-lesion area in Ve （ F=1 .553 ,P ＆gt;0 .05） .The sensitivity of Ktrans and Ve was 73 .4% and 54 .3% ,and the specificity of those was 82.7%and 47 .9% ,for differential diagnosis between prostate cancer and benign hyperplasia in central zone with the maximum Youden’ index as cut off .Conclusion Ktrans derived from 3 .0T DCE MRI is valuable in the differential diagnosis of central zone prostate cancer from benign hyperplasia while Ve is not much sence .
出处
《医学影像学杂志》
2014年第5期824-827,共4页
Journal of Medical Imaging
关键词
前列腺癌
磁共振动态对比增强
Prostate cancer
Dynamic contrast-enhanced M RI
