摘要
目的探讨地佐辛治疗急诊胆绞痛患者疼痛的安全性及有效性。方法急诊胆绞痛患者126例，随机分为3组，分别肌内注射地佐辛（10mg）、哌替啶（100mg）及山莨菪碱（10mg）。记录给药前后各时点VAS评分、HR和MAP及不良反应。结果地佐辛组在给药后5、10、30、60、120、240min时VAS评分均低于哌替啶组和山莨菪碱组（P〈0．05）。3组患者各时点组内及组间HR、MAP比较差异无统计学意义（P〉0．05）。地佐辛组口干、视物模糊及心动过速的发生率均低于哌替啶组和山莨菪碱组（P〈0．05）。结论地佐辛用于急诊胆绞痛的镇痛效果优于哌替啶和山莨菪碱，且不良反应发生率较低。
Objective To explore the safety and analgesic efficacy of dezocine in the treatment of patients with acute biliary colic. Methods One hundred and twenty-six patients with acute biliary colic were randomly divided into 3 groups, received intramuscular injection of dezocine 10 mg, pethidine 100 mg and anisodamine 10 mg respectively. VAS, HR, MAP and adverse reactions were recorded at each time points before and after the treatment. Results VAS was significantly lower in dezocine group than that in the other groups at 5, 10, 30, 60, 120, 240 min after the treatment （P〈0. 05）. No difference was found in the HR and MAP at each time points after the treatment among the three groups （P〈0. 05）. The incidences of dry mouth, blurred vision and tachycardia were significantly lower in dezocine group than those in the other groups. Conclusion Compared with pethidine and anisodamine, the analgesic efficacy of dezocine is better, with less adverse effects.
出处
《实用疼痛学杂志》
2013年第6期442-444,共3页
Pain Clinic Journal
关键词
地佐辛
胆结石
绞痛
急性病
哌替啶
山莨菪碱
镇痛
Dezocine
Cholelithiasis
Colic
Acute disease
Pethidine
Anisodamine
Analgesia
