摘要
目的:观察匹维溴铵联合酪酸梭菌肠球菌三联活菌片治疗肠易激综合征(IBS)的疗效和安全性。方法:将195例IBS患者随机分为3组(A组70例,B组60例,C组65例),A组患者口服匹维溴铵50 mg,tid,并口服酪酸梭菌肠球菌三联活菌片0.4 g,tid;B组和C组患者分别单独口服匹维溴铵和酪酸梭菌肠球菌三联活菌片,用法用量同A组。观察3组患者的临床症状和不良反应发生情况,并于治疗8周后比较3组患者总的疗效。结果:A组患者总有效率为97.10%,显著高于B组(85.00%)和C组(81.54%),差异均有统计学意义(P<0.05);A组患者在缓解腹胀、腹痛和改善排便频率、大便性状等方面均显著优于B组(P<0.05或0.01),但在改善排便频率、大便性状方面与C组相似(P>0.05)。3组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:匹维溴铵联合酪酸梭菌肠球菌三联活菌片治疗IBS疗效优于单用组。对于胃肠道感觉异常为主要症状的IBS患者可以单独使用匹维溴铵治疗;若IBS的主要症状以排便频率及大便性状异常为主,则单独使用酪酸梭菌肠球菌三联活菌片也可达到较好疗效。
OBJECTIVE： To observe the curative efficacy and safety of pinaverium bromide combined with Clostridium butyricure Enterococcus triple viable bacterial tablets for irritable bowel syndrome （IBS）. METHODS： 195 IBS cases were randomly divided into group A （70 cases）, group B（60 cases） and group C（65 cases）. Group A was treated with pinaverium bromide 50 mg and C. butyricum Enterococcus triple viable bacterial tablets 0.4 g, tid, po; group B was treated with pinaverium bromide 50 mg alone and group C was treated with pinaverium bromide 50 mg or C. butyricum Enterococcus triple viable bacterial tablets 0.4 g alone, tid, po. The symptoms and ADR of 3 groups were observed, and curative efficacies of 3 groups were compared after 8 weeks of treatment. RESULTS： The total effective rate was 97.10% in group A, which was significantly higher than 85.00% of group B and 81.54% of group C; there was statistical significance （P〈0.05）. The improvement of abdominal pain and distension, frequency of defecation, shape and properties of defecation in group A were all better than those of group B（P〈0.05 or P〈0.01） ; the last 2 indicators of group A were similar to those of group C（P〉0.05）. There was no statistical significance in the rate of ADR among 3 groups （P〉0.05）. CONCLUSIONS： Curative efficacy of pinaverium bromide combined with C. butyricum Enterococcus triple viable bacterial tablets is better than single drug in the treatment of IBS. IBS patients suffering from gastrointestinal abnormality as main symptom can receive Pinaverium bromide tablets alone. To treat main symptom of IBS as disorder of defecation, abnormal shape and properties of defecation, C. butyricum Enterococcus triple viable bacterial tablets alone can obtain sound curative efficacy.
出处
《中国药房》
CAS
CSCD
2014年第24期2245-2247,共3页
China Pharmacy
关键词
酪酸梭菌肠球菌三联活菌片
匹维溴铵
肠易激综合征
疗效
安全性
Clostridium butyricum Enterococcus triple viable bacterial tablets
Pinaverium bromide
Irritable bowel syndrome
Curative efficacy
Safety
