摘要
目的 :观察大剂量胸腺肽 ( thymopeptide,TP)对恶性肿瘤放疗病人 T细胞亚群的影响。方法 :51例恶性肿瘤放疗病人分为 10 0 mg和 2 0 0 mg胸腺肽用药组。病人分别每日静点胸腺肽 10 0 mg和 2 0 0 mg,连续 10日用药。用流式细胞仪测其用药前后外周血 T细胞 CD4、CD8、CD2 5和 CD56阳性百分率。结果 :10 0 mg用药组病人用药后外周血 T细胞 CD4和 CD2 5阳性百分率明显高于用药前水平( P<0 .0 5) ,而 2 0 0 mg用药组病人用药后外周血 T细胞 CD4、CD8、CD2 5和 CD56阳性百分率均明显增高 ( P<0 .0 5或 P<0 .0 1)。结论 :大剂量胸腺肽可在短时间内提高恶性肿瘤放疗病人细胞免疫功能 ,而且每日 2 0 0 mg用药量效果更佳。
Objective:To study effects of large dose thymopeptides on T cell subpopulations of patients with malignant tumor under radiotherapy.Methods:Fifty one patients with malignant tumor under radiotherapy were divided into 2 groups with 100 mg and 200 mg thymopeptides respectively.The patients were given thymopeptides,100 mg/d or 200 mg/d,iv, for 10 days.The positive percentages of CD4,CD8,CD25 and CD56 in T cells of peripheral blood before and after thymopeptide treatment were determined by flow cytometry. Results:The positive percentages of CD4 and CD25 in T cells of peripheral blood after 100 mg/d thymopeptide treatment were significantly higher than those before thymopeptide treatment ( P <0 05),while those of CD4,CD8,CD25 and CD56 in T cells of peripheral blood after 200 mg/d thymopeptide treatment all increased significantly ( P <0 05 or P <0 01).Conclusion:These results suggest that large dose of thymopeptides can increase immune function of patients with malignant tumor under radiotherapy,and the curative effect of 200 mg/d thymopeptides is better. [
出处
《白求恩医科大学学报》
CAS
CSCD
北大核心
2001年第2期168-170,共3页
Journal of Norman Bethune University of Medical Science
