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不同类别抑郁的MRI特征及其对首发抑郁早期定性诊断研究的启示 被引量：4

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摘要 流行病学研究显示重度抑郁发作是单相重度抑郁障碍以及50％双相障碍患者的首发症状[1],而以重度抑郁发作为首发症状的双相障碍患者往往被延误诊断[2],尤其是青少年发病者中被误诊率更高.单相重度抑郁障碍、双相障碍及难治性抑郁障碍的治疗方案存在明显的差异,而早期的准确定性诊断有助于早期优化治疗方案的制定.鉴于诊断技术的限制,目前首发抑郁诊断归类的早期定性指标仍不明确,导致早期诊断存在不确定性,而早期诊断的不确定性严重影响了患者临床治疗方案的决策及治疗结局[3].分析有关不同类别的抑郁发作的特异性生物学标记研究的文献,归纳总结不同诊断类别抑郁发作的特征性标记,在此基础上在首次抑郁发作患者中进行大样本纵向前瞻性随访研究,通过纵向随访来考察疾病转归情况并检验这些特异性生物学标记的稳定性以及作为早期定性诊断指标的信度及效度,将有助于提高双相障碍、单相重度抑郁障碍、难治性抑郁障碍的早期正确识别率.遵循这一研究思路,本文对既往部分研究文献进行综述,以增进对此研究领域的了解.
作者 禚传君
机构地区 天津市安宁医院
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2014年第5期477-478,共2页 Chinese Journal of Behavioral Medicine and Brain Science
关键词 抑郁障碍 早期诊断 首发症状 定性诊断 MRI特征 抑郁发作 生物学标记 双相障碍
分类号 R749.4 [医药卫生—神经病学与精神病学]
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共引文献54

同被引文献74

  • 1刘思红,李春丽.重复经颅磁刺激联合抗抑郁药治疗对抑郁症首发患者的早期疗效及认知功能改善的观察[J].心理月刊,2020(16):53-53. 被引量：6
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中华行为医学与脑科学杂志
2014年 第5期

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