摘要
目的系统评价放化疗联合热疗治疗中晚期宫颈癌的疗效和安全性。方法计算机检索h e Cochrane Library(2013年7期)、PubMed、EMbase、CBM、VIP、CNKI和WanFang Data数据库,检索时限均为从建库至2013年7月,纳入有关放化疗联合热疗治疗中晚期宫颈癌的文献。由2名评价员按照纳入与排除标准独立筛选文献、提取资料和评价质量后,采用RevMan 5.2软件进行Meta分析。结果共纳入9个RCT,693例患者。Meta分析结果显示:与放化疗组相比,放化疗联合热疗组的1年生存率[OR=3.05,95%CI(1.70,6.68),P=0.005]、2年生存率[OR=2.29,95%CI(1.19,4.38),P=0.01]、总有效率[OR=3.66,95%CI(2.31,5.81),P<0.000 01]均明显上升,且差异有统计学意义,但两组不良反应发生率差异无统计学意义。结论放化疗联合热疗能明显提高中晚期宫颈癌患者的远期和近期疗效。但受纳入研究数量和质量的限制,上述结论仍有待更多高质量的研究予以验证。
Objective To systematically review the efficacy and safety of radio-chemotherapy combined with thermotherapy for cervical cancer. Methods Literature about the efficacy and safety of radio-chemotherapy combined with thermotherapy for patients with cervical cancer at mid-term/advanced stage was retrieved from digital databases of The Cochrane Library （Issue 7, 2013）, PubMed, EMbase, CBM, VIP, CNKI, and WanFang Data, and from their established dates to July, 2013. Data extraction and quality assessment of included studies were conducted by two reviewers independently. RevMan 5.2 software was then used to perform meta-analysis. Results A total of 9 randomized controlled trials involving 693 patients were included. The results of meta-analysis showed that, compared with the radio-chemotherapy alone group, the radio-chemotherapy combined with thermotherapy group had significant increased 1-year survival rates （OR=3.05, 95%CI 1.70 to 6.68, P=0.005）, 2-year survival rates （OR=2.29, 95%CI 1.19 to 4.38, P=0.01）, and overall effective rates （OR=3.66, 95%CI 2.31 to 5.81, P〈0.000 01）. The incidence of adverse reactions was no statistically significant between the two groups. Condusion Radio-chemotherapy combined with thermotherapy improves long-term survival rates and short-term curative effects for patients with cervical cancer at mid-term/advanced stage. However, due to the limited quantity and quality of the included studies, more high quality studies with large sample size and long-term follow-up are still needed to verify the above conclusion.
出处
《中国循证医学杂志》
CSCD
2014年第6期752-758,共7页
Chinese Journal of Evidence-based Medicine
关键词
宫颈癌
热疗
放疗联合化疗
META分析
系统评价
随机对照试验
Cervical cancer
Thermotherapy
Radio-chemotherapy
Meta-analysis
Systematic review
Randomized controlled trial
