摘要
目的 评价放射治疗结合不同化疗方案治疗不能手术的Ⅲ期非小细胞肺癌 (NSCLC)疗效。方法 6 2例不能手术的Ⅲ期NSCLC患者随机分为 2个组 :2 9例每周接受 1次紫杉醇 30mg、顺铂30mg化疗 (紫杉醇组 ) ,33例每周接受 1次依托泊甙 (VP 16 ) 10 0mg、顺铂 30mg化疗 (VP 16组 )。连续5～ 6周 ,均同时配合常规分割放射治疗 (2Gy/次 ,5次 /周 ) ,照射野包括肺部原发灶和纵隔淋巴引流区 ,总剂量为 6 0～ 70Gy。结果 紫杉醇组总有效率 (CR +PR)为 82 .8% ,完全缓解 (CR)率为 10 .3% ,VP 16组总有效率为 5 4.6 % ,CR率为 18.0 %。 2个组总有效率差异有显著性意义 (χ2 =4.41,P =0 .0 38)。中位生存期、1、2年生存率紫杉醇组分别为 12 .8个月、5 2 .2 %、2 7.3% ,VP 16组分别为 9.8个月、42 .8%、18.4% ,2个组差异无显著性意义。化疗的毒副作用主要是骨髓抑制和消化道反应 ,但均可耐受。结论 紫杉醇组治疗不能手术的Ⅲ期NSCLC近期有效率明显优于VP 16组 ,但不提高生存率。
Objective To evaluate the effect of concomitantdifferent regimens chemotherapy and radiotherapy for inoperable stage Ⅲ non small cell lung cancer (NSCLC). Methods From September 1995 to December 1998, 62 patients with inoperable stage Ⅲ NSCLC were randomized into two groups. Twenty nine patients received paclitaxel 30 mg and cisplatin 30 mg weekly for 5～6 weeks (paclitaxel group), and 33 patients received etoposide (Vp 16) 100 mg and cisplatin 30 mg weekly for 5～6 weeks (VP 16 group). All patients received concomitant radiotherapy as well. Radiotherapy was given with conventional fraction in 2Gy per fraction and five fractions per week. The total tumor doses were 60～70 Gy. Treatment fields covered clinical tumor and lymph node involved. Results The overall response (CR+PR) rate in paclitaxel group was 82.8% with a complete response (CR) rate of 10.3%. The overall response rate in the VP 16 group was 54.6% with a CR rate of 18%. The difference of overall response rate between the two groups was statistically significant (P<0.05). The median survival time, 1 , and 2 year survival rates were 12.8 months, 52.2%, and 27.3% for paclitaxel group, and 9.8 months, 42.8%, and 18.4% for the VP 16 group (P>0.05). The major toxic effects of chemotherapy were gastrointestinal tract reaction and myelosuppression. Conclusions Concomitant chemotherapy of paclitaxel plus cisplatin and radiotherapy for inoperable stage Ⅲ NSCLC is acceptable, and its efficacy is superior to cisplatin plus etoposide combined with radiotherapy.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2001年第1期31-33,共3页
Chinese Journal of Radiation Oncology
关键词
Ⅲ期非小细胞癌
放射疗法
药物疗法
综合治疗
NSCLC
Non small cell lung carcinoma/radiotherapy
Non small cell lung carcinoma/drug therapy
Combined modality therapy
