摘要
骨性关节炎 （ osteoarthritis，OA ） 是一种常见的退行性关节病，涉及到整个滑膜关节，包括软骨、滑膜和软骨下骨。OA主要的临床表现是关节的疼痛，这不仅会导致功能受限和生活质量的降低，而且是老年人行动不利的主要原因[1]。有报道，60岁以上的人群中，50%在X线片上有骨性关节炎表现，80%有骨性关节炎症状，并且是致残的主要原因之一[2]。尽管目前对于OA疼痛的确切机制尚不明确，但普遍认为其与膝关节局部炎症相关，炎症细胞因子通过直接或间接的途径诱导痛觉过敏是OA疼痛的原因之一。
In order to provide theoretical basis for the clinical treatment of osteoarthritis, the mechanism of inflammatory cytokines in osteoarthritis pain was investigated. A computer-based search of PubMed and China National Knowledge Infrastructure （ CNKI ） database was performed for the related articles with the keywords of＂inflammatory cytokines, interleukin, tumor necrosis factor, chemokines, osteoarthritis pain, neuropathic pain and biochemical mechanisms＂in English or in Chinese. The literatures related to the mechanism of inlfammatory cytokines in osteoarthritis pain were selected. A total of 84 literatures were primarily selected and 42 articles were reviewed according to the inclusion criteria. Osteoarthritis pain is one of the main factors affecting the life quality of the patients, and a variety of abnormal cells of the peripheral and central nervous systems were involved. Inlfammatory cytokines played an important role in the pathogenesis of osteoarthritis. The relationship between osteoarthritis pain and common inlfammatory cytokines were reviewed in the review, so as to explore the important role of inlfammatory cytokines in osteoarthritis pain and provide theoretical basis for the clinical treatment of osteoarthritis.
出处
《中国骨与关节杂志》
CAS
2014年第5期374-377,共4页
Chinese Journal of Bone and Joint
