摘要
目的研究慢性心力衰竭(CHF)患者血清结缔组织生长因子(CTGF)的变化及临床意义。方法测定105例CHF患者血清CTGF含量及左心室射血分数(LVEF)、左心室质量指数(LVMI)变化,进行相关分析,并选取68例健康人做为对照组。结果CHF患者血清CTGF水平均显著高于对照组(P〈0.01);血清CTGF升高水平与心力衰竭严重程度相平行;血清CTGF水平与LVEF呈负相关,与LVMI、心功能分级呈正相关。结论血清CTGF参与了CHF的病理生理过程,血清CTGF水平可作为诊断及判断心力衰竭严重程度的生物学指标。
Objective To study the changes of serum connective tissue growth factor (CTGF) levels in patients with chronic heart failure (CHF) and its clinical implications. Methods The serum CTGF levels and the left ventricular ejection fraction( LVEF), left ventricular mass index(LVMI) of 105 patients with CHF and 68 control subjects were measured and analyzed. Results The serum CTGF level in patients with CHF was significantly higher than that in the control group (P 〈 0.01 ) ; The increased level of serum CTGF was parallelled with the severity of heart failure; The serum CTGF level was nega- tively correlated with LVEF, and positively correlated with LVMI and cardiac function classification. Conclusions Serum CTGF participate in the pathological and physiological process of CHF, so serum CTGF level can be used as biological index of diagnosis and judgement of the severity of heart failure.
出处
《中国实用医刊》
2014年第13期30-31,共2页
Chinese Journal of Practical Medicine
关键词
心力衰竭
结缔组织生长因子
Heart failure
Conective tissue growth factor