摘要
目的观察妊娠合并生殖道感染的干预治疗对胎膜早破(PROM)的预防作用。方法选择妊娠合并生殖道感染治疗组200例,妊娠合并生殖道感染未治疗组70例,妊娠无生殖道感染为正常对照组300例,观察三组胎膜早破发生率,观察绒毛膜羊膜炎发生率,并行免疫组织化学技术检测三组胎膜中基质金属蛋白酶-9(MMP-9)及金属蛋白酶组织抑制因子-1(TMP-1)的表达率。结果感染治疗组胎膜早破发生率低于感染未治疗组,高于正常对照组;感染未治疗组MMP-9 PU比值及MMP-9/TMP-1 PU比值高于治疗组和正常对照组;3组中TMP-1的PU值比较差异无统计学意义(P>0.05)。结论妊娠合并生殖道感染可提高胎膜中MMP-9表达率从而提高胎膜早破发生率,经过针对性治疗可有效减少胎膜早破及不良妊娠结局的发生。
Objective To explore the preventive effect on PROM by curing genital tract infection during pregnancy. Methods Totally 200 case of pregnancy with genital tract infection（GTI） with treatment,70 case of pregnancy with GTI without cure ,300 case of pregnancy without GTI. Explored the incidence of premature rupture of membranes （PROM） and the incidence of chorioamnionitis, the expression level of MMP - 9 and TMP - 1 was detected in membranes of three groups by immunohistochemistr. Results PROM incidence of GTI treatment group lower than that of GTI untreated group and higher that in normal control group（ P 〈 0. 05 ） ; The expression level of MMP - 9 and MMP - 9/TMP - 1 of GTI untreated group higher that in GTI treatment group and normal control group （ P 〈 0. 05 ） ; The expression level of TMP - 1 among three groups has no statistical significance （ P 〉 0. 05 ）. Conclusion GTI can improve the expression level of MMP- 9 and increase the incidence of PROM during pregnancy, the treatment of GTI with the PROM and the adverse pregnancy outcomes should be strengthened.
出处
《医药论坛杂志》
2014年第5期33-35,共3页
Journal of Medical Forum
基金
郑州市2012年度科技计划项目(N2012S0687)
关键词
妊娠
生殖道感染
胎膜早破
基质金属蛋白酶-9
金属蛋白酶组织抑制因子-1
Genital tract infection（GTI）
Premature rupture of membranes（PROM）
Matrix metallopeptidase 9 （MMP- 9 ）
Tissue inhibitor of matrix metalloproteinase 1 （ TMP - 1 ）
